Impact of ABO rs505922 Genetic Variant on Angiotensin-Converting Enzyme Activity in Thai Population

Abstract

ABO polymorphisms have been reported to associate with angiotensin converting enzyme (ACE) inhibitor-induced cough and ACE activity. This study aimed to investigate frequencies of ABO rs505922C>T SNP in Thais and compare them to that in other ethnicities. The impact of this SNP on ACE activity in the Thai population was also determined. Genomic DNA from 100 healthy Thai volunteers was isolated from whole blood and genotyping. The serum ACE activity was assessed. Significant differences in T allele frequencies for rs505922C>T were noticed between Thais (0.48) and Caucasians (0.65) (p = 0.022). However, the frequency of T allele was not significantly different between Thai and Japanese populations (0.55) (p = 0.396). Thai subjects with TT genotype had significantly lower serum ACE activity (median: 26 U/L; n=25) than subjects with CT genotype (median: 32 U/L; n=45) (p = 0.018). The impact of this SNP was significant in females (p = 0.021). Moreover, serum ACE activity tended to be lower in subjects with TT genotype compared to CC genotype (median: 29, U/L; n=30) (p = 0.480). The ABO rs505922C>T has an impact on serum ACE activity in the Thai population. There were variant allele frequency differences between Thais and Caucasians. Clinical trials for Thai patients with ACE inhibitor-induced cough are required to evaluate the effects of this SNP on ACE activity.