@article{Panthong_Itharat_Aukkanibut_Intarawan_2020, title={Anti-inflammatory Effect and Total Flavonoid Content of The Ethanolic Seed Extracts of Three Umbelliferae Species}, volume={25}, url={https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/208653}, abstractNote={<p>The seeds of three plants in Umbelliferae, namely <em>Anethum graveolens</em>, <em>Cuminum cyminum</em> and <em>Foeniculum vulgare</em> are used as ingredients in Thai traditional medicine for treating inflammation. Additionally, they are macerated in alcohol and used as a Thai traditional drug. Although <em>A. graveolensm</em>, <em>C. cyminum</em> and <em>F. vulgare</em> are members of the same family, these plants consist in chemical constituent. There are no studies comparing their anti-inflammatory properties. Our objectives were to investigate and compare the anti-inflammatory activity and total flavonoid content of the ethanolic seed extracts of these three species. Results showed that <em>F. vulgare</em> extract had the highest activity in inhibiting nitric oxide, IL-6 production and the highest flavonoid content. The ethanolic extract of <em>C. cyminum</em> showed moderate anti-inflammatory activity while <em>A. graveolens</em> showed no inhibition of nitric oxide, TNF-<img title="\alpha" src="https://latex.codecogs.com/gif.latex?\alpha"> and IL-6 production. <em>F. vulgare</em> extract had the best anti -inflammatory properties that were related to total flavonoid content and should be now be assessed in animal models.</p>}, number={4}, journal={Science & Technology Asia}, author={Panthong, Sumalee and Itharat, Arunporn and Aukkanibut, Sasikarn and Intarawan, Thanaporn}, year={2020}, month={Dec.}, pages={174–181} }