TY - JOUR AU - Saenmuang, Phadungnaree AU - Panthong, Sumalee AU - Itharat, Arunporn PY - 2020/09/21 Y2 - 2024/03/28 TI - Antibacterial Activity of Mahajak Remedy and Plant Ingredients: Antibacterial activity of Mahajak remedy JF - Science & Technology Asia JA - Sci Tech Asia VL - 25 IS - 3 SE - DO - UR - https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/223184 SP - 78-86 AB - <p>Mahajak (MH) oil is a remedy in Tamra-Osodpranarai. It is used for relieving pain, and skin infection as a Thai traditional medicine. This study investigated the efficacy of the MH remedy and plant ingredient extract on antibacterial activities. The MH remedy was macerated with sesame oil, 95% ethanol, hexane, and its plant ingredients were macerated with 95% ethanol. Then, all extracts were concentrated by rotary evaporator. The extracts were investigated on antibacterial activity against <em>Staphylococcus aureus</em> ATCC 25923, <em>Pseudomonas aeruginosa</em> ATCC 9027, and <em>Bacillus subtilis</em> ATCC 6633 by disc diffusion method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results show that the 95% ethanol extract of MH remedy was the best extract of antibacterial testing. Using the disc containing 10 μL (concentrate 500 mg/mL of the extracts), the inhibition zone was observed against <em>S. aureus</em> (9.67±0.33 mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 2.50 mg/mL were obtained for residue hexane. Hexane extracts showed MIC and MBC of <em>S.aureus</em> and <em>B.subtilis</em> with similar values to 95% ethanol. However, all of the tests had no inhibitory activity against <em>P.aeruginosa</em>. In conclusion, this study demonstrated that 95% ethanol extracts of the MH remedy have antibacterial activity and may be a potential treatment in cases of skin infection.</p> ER -