Formulation of Fenofibrate-Loaded Lipid Nanoparticles Using High Pressure Homogenisation

Abstract

In this study, fenofibrate-loaded lipid nanoparticles (LNs) were successfully produced by hot high pressure homogenisation technique. The preliminary studies revealed that processing parameters, for example, homogenised cycle and pressure, and the amount of lipid, were crucial factors affecting the particles size of blank LNs. At the optimal conditions, fenofibrate-loaded LNs with a median particle size of 189 nm, d(0.9) value of 265 nm and span value of 0.6 could be obtained. Processing parameters, such as the types of co-lipid, as well as the incorporation of lecithin played a significant role in controlling the particle size. The nano-sized range formulation could be achieved by using small molecular structure lipid and employing 1.25%w/w of lecithin.