Rational use of Antibiotic Prophylaxis during Childbirth: A Case of Community Hospital in Northeastern Thailand

Authors

  • Punnawadee Upanan Student, Master of Pharmacy Program in Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
  • Waraporn Juntarat Obstetrician, Department of Medicine, Yangtalat Hospital, Kalasin, Thailan
  • Suthan Chanthawong Assistant Professor, Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
  • Cheardchai Soontornpas Associate Professor, Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand

Keywords:

Childbirth, Delivery, Antibiotic prophylaxis, Rational use

Abstract

Irrational antibiotic use has become the national agenda both in Thailand and other countries worldwide. This prospective cohort study was conducted to determine the prevalence and the rational use of antibiotic prophylaxis during childbirth among pregnant women who were admitted to Yangtalat Hospital, Kalasin Province between 1 January and 30 June 2020. Data were collected from medical records and patient interviews during hospitalization and after hospital discharge. A total of 270 participants were recruited in the study. There were 127 and 143 women with vaginal delivery and caesarean section, respectively. Antibiotic prophylaxis was prescribed in 139 participants (51.5%). The percentage of appropriateness of prescribing antibiotic prophylaxis was 97.8%. Peripartum infections were presented in 8.9%. In conclusion, most of antibiotic prophylaxis is rational with low incidence of complications.

References

World Health Organization. WHO recommendations for prevention and treatment of maternal peripartum infections. [Online]. [cited Jun 30, 2019].2016. Available from: https://www.who.int/publications/i/item/9789241549363.

Kawakita T, Landy HJ. Surgical site infections after cesarean delivery: epidemiology, prevention and treatment. Maternal Health Neonatol Perinatol. 2017;3(12):1-9.

Shi M, Chen L, Ma X, Wu B. The risk factors and nursing countermeasures of sepsis after cesarean section: a retrospective analysis. BMC Pregnancy Childbirth. 2022;22(696):1-7.

Bonet M, Ota E, Chibueze CE, Oladapo OT. Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity. Cochrane Database Syst Rev. 2017;11(11):CD012137.

Ministry of Public Health. Health Data Center [online]. 2020 [cited Sep 14, 2022]. Available from: https://kkn.hdc.moph.go.th/hdc/reports/page_kpi.php?flag_kpi_level=1&flag_kpi_year=2020.

Kritsadathan T, Phithakham C, Piyamongkol W. Antibiotic prophylaxis in vaginal delivery of normal term labour at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai. Chiang Mai Med J. 2019;58(4):233-243.

Chutimaporn C, Piriya T, Supaporn S, Sarawut M, Surasak C. Effect of rational drug use policy on antibiotic prophylaxis use in normal vaginal delivery in Mahasarakham Hospital. Journal of Health Systems Research. 2019;13(3):261-270.

The Sub-Committee on Rational Drug Use. Rational drug use hospital manual. 1st ed. Bangkok: The Agricultural Cooperative Federation of Thailand; 2015.

Ploungbunmee S, Disorntatiwat P, Bumrungphuet S, Rotjananirankit N. Clinical outcomes of antibiotic prophylaxis in vaginal delivery women at Ramathibodi Hospital. Rama Med J. 2019;42(3):12-23.

Leth RA, Moller JK, Thomsen RW, Uldbjerg N, Norgaard M. Risk of selected postpartum infections after cesarean section compared with vaginal birth: A five-year cohort study of 32,468 women. Acta Obstet Gynecol Scand. 2009;88(9):976-983.

Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 199: use of prophylactic antibiotics in labor and delivery. Obstet Gynecol. 2018;132(3):e103-119.

American Society of Health-System Pharmacists. Clinical practice guidelines for antimicrobial prophylaxis in surgery. [Online]. [cited Jun 30, 2019].2013. Available from: https://www.ashp.org/surgical-guidelines

Sutatworawut S, Changsamorn P, PoonKhum Y, Aiumkong P, Intarapaserd S, Saejung K. Reproductive heath service. 2nd ed. Minister of Public Health, editor. Bangkok: The war veterans organization printing.

Klaitabtim B. Natural Childbirth: Care Guideline. Songklanagarind J Nurs. 2018;38(1):111-119.

World Health Organization. A healthy lifestyle - WHO recommendations. [Online]. [cited Mar 19, 2022].2010. Available from: https://www.who.int/europe/news-room/fact-sheets/item/a-healthy- lifestyle---who-recommendations

Sirilak T, Kanjanarat P, Nochaiwong S, Katip W. Incidence of postpartum infections and outcomes associated with antibiotic prophylaxis after normal vaginal birth. Front Med. 2022;9:939421.

Liu R, Lin L, Wang D. Antimicrobial prophylaxis in caesarean section delivery. Exp Ther Med 2016;12(2):961-964.

Downloads

Published

2024-04-14

Issue

Vol. 24 No. 1 (2024)

Section

บทความวิจัย

License

Copyright (c) 2024 KKU Research Journal (Graduate Studies)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.