Incidence of AKI-CKD Transition in Chaiyaphum Hospital

Abstract

Acute kidney injury (AKI) is a condition in which kidney function decreases rapidly and it is a risk factor of chronic kidney disease (CKD). This study aimed to determine the incidence of CKD and change in glomerular filtration rate. The study design was a retrospective data and data were collected among hospitalized patients diagnosed with AKI at Chaiyaphum Hospital. A total of 281 patients were included in the study, 107 were non-CKD patients and 174 were patients with a prior history of CKD. The results showed was found that after 1 year of AKI, there were 39 new cases of CKD (36.4%) or the incidence of new cases of CKD was 37.8 per 100 person-years and 30 end-stage renal disease patients (10.7%), accounting for an incidence of 10.4 per 100 person-years. After 1 year of follow-up, the glomerular filtration rate (eGFR) was 46.00 (26.50, 73.50) ml/min/1.73m² compared to the baseline of eGFR 54.00 (35.00, 80.50) ml/min/1.73m² which was statistically significant decrease (p-value<0.001). In conclusion, AKI can lead to the progression of new CKD and has a deteriorating effect on pre-existing CKD and also had a statistically significant decrease in glomerular filtration value.