A Modified Exact Reconstruction Algorithm to Determine the Complex Permittivity Perturbations of a Cancer-Affected Biological Target Using the Microwave Tomography Technique

Main Article Content

Deborsi Basu
Kabita Purkait

Abstract

As an emerging technology, the microwave tomography technique (MTT) is demonstrating its effectiveness in detecting cancer at an early stage. Due to the random, non-deterministic characteristics of cancer cells, more advancements are required in MTT to accurately detect the presence and location of the affected region. In this paper, we consider this fundamental issue and propose a modified exact reconstruction algorithm (mERA) capable of providing a detailed analysis of all kinds of complex dielectric perturbations in any cancer-affected biological target. In MTT, the detection of a cancerous tumor inside any organ of the human body is performed using different image reconstruction algorithms. In contrast, the proposed algorithm in this study uses a selective data segregation mechanism to generate the perturbed complex cell permittivity of the affected organ tissues. The efficiency of our approach in detecting all types of dielectric variations such as large (20%), small (5%), positive or negative has also been verified, even in a mixed scenario where affected cells possess all types of perturbations simultaneously. As a cancerous cell shows peculiar behavior inside the human body and its nature varies from person to person and even in between the different stages (1, 2, 3, and 4) of cancer, the algorithm is designed in such a way that it can detect the presence of a tumor taking all these possibilities into account. The results validate the high accuracy and effectiveness of the proposed mERA in the field of cancer diagnosis.

Article Details

How to Cite
Basu, D., & Purkait, K. (2021). A Modified Exact Reconstruction Algorithm to Determine the Complex Permittivity Perturbations of a Cancer-Affected Biological Target Using the Microwave Tomography Technique. ECTI Transactions on Electrical Engineering, Electronics, and Communications, 19(3), 340–352. https://doi.org/10.37936/ecti-eec.2021193.244937
Section
Publish Article

References

S. Hosseinzadegan, “Fast Microwave Tomography Algorithm for Breast Cancer Imaging,” Ph.D. dissertation, Dept. Elect. Eng., Chalmers University of Technology, Göteborg, Sweden, 2021.

D. Kurrant, M. Omer, N. Abdollahi, P. Mojabi, E. Fear, and J. LoVetri, “Evaluating Performance of Microwave Image Reconstruction Algorithms: Extracting Tissue Types with Segmentation Using Machine Learning,” Journal of Imaging, vol. 7, no. 1, 2021, Art. no. 5.

Y. Zhang, Y. Ma, A. Omrani, R. Yadav, M. Fjeld, and M. Fratarcangeli, “Automated Microwave Tomography (MWT) Image Segmentation: State-of-the-Art Implementation and Evaluation,” Computer Science Research Notes, CSRN 3001, pp. 126–136, 2020.

E. R. Almeida, T. Bicudo, and J. L. Porsani, “Automatic estimation of inversion parameters for Microwave Tomography in GPR data using cooperative targets,” Journal of Applied Geophysics, vol. 178, Jul. 2020, Art. no. 104074.

International Agency for Research on Cancer (IARC), “Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018,” World Health Organization, Lyon, France, Press Release No. 263, Sep. 12, 2018. [Online]. Available: https://www.who.int/cancer/PRGlobocanFinal.pdf

L. Wang, “Early Diagnosis of Breast Cancer,” Sensors, vol. 17, no. 7, 2017, Art. no. 1572.

B. Sohani et al., “Detection of haemorrhagic stroke in simulation and realistic 3-D human head phantom using microwave imaging,” Biomedical Signal Processing and Control, vol. 61, 2020, Art. no. 102001.

T. Reimer, M. Solis-Nepote, and S. Pistorius, “The Application of an Iterative Structure to the Delay-and-Sum and the Delay-Multiply-and-Sum Beamformers in Breast Microwave Imaging,” Diagnostics, vol. 10, no. 6, 2020, Art. no. 411.

A. K. Trull, J. van der Horst, L. J. van Vliet, and J. Kalkman, “Comparison of image reconstruction techniques for optical projection tomography,” Applied Optics, vol. 57, no. 8, pp. 1874–1882, 2018.

A. K. Kundu, B. Bandyopadhyay, and S. Sanyal, “A Microwave Imaging and Enhancement Technique from Noisy Synthetic Data,” ANNALS of Faculty Engineering Hunedoara – International Journal of Engineering, vol. 9, no. 1, pp. 175–178, 2011.

K. Purkait, D. Basu, and N. R. Das, “An Approach To A Narrow Beam Antenna For Microwave Scanning Of Stroke Affected Brain Cells,” Indian Science Cruiser, vol. 32, no. 3, pp. 43–46, May 2018.

K. Purkait, D. Basu, and N. R. Das, “Study of Beamwidth Variation of Dipole Array Antenna for Microwave Scanning of Biological Target,” International Journal on Recent and Innovation Trends in Computing and Communication, vol. 6, no. 1, pp. 120–123, Jan. 2018.

J. Richmond, “Scattering by a dielectric cylinder of arbitrary cross section shape,” IEEE Transactions on Antennas and Propagation, vol. 13, no. 3, pp. 334–341, May 1965.

A. N. Datta and D. B. Bandyopadhyay, “An Improved SIRT-Style Reconstruction Algorithm for Microwave Tomography,” IEEE Transactions on Biomedical Engineering, vol. BME-32, no. 9, pp. 719–723, Sep. 1985.

S. Mandal and K. Purkait, “A Modified Exact Reconstruction Algorithm for Microwave Tomography for Detection of Disease in Human Body,” International Journal of Tomography & Statistics, vol. 18, no. F11, pp. 82–93, 2011.

S. Saha, G. Pal, S. Pyne, and S. Mandal, “Tomography of Human Body using Exact Simultaneous Iterative Reconstruction Algorithm,” Computer Science & Information Technology, vol. 3, no. 2, pp. 437–443, 2013.

J. H. Jacobi, L. E. Larsen, and C. T. Hast, “Water-Immersed Microwave Antennas and Their Application to Microwave Interrogation of Biological Targets,” IEEE Transactions on Microwave Theory and Techniques, vol. 27, no. 1, pp. 70–78, Jan. 1979.

L. E. Larsen and J. H. Jacobi, “Microwave scattering parameter imagery of an isolated canine kidney,” Medical Physics, vol. 6, no. 5, pp. 394–403, Sep. 1979.

A. Joisel et al., “Microwave imaging techniques for biomedical applications,” in Proceedings of the 16th IEEE Instrumentation and Measurement Technology Conference (IMTC/99), vol. 3, 1999, pp. 1591–1596.

J. C. Bolomey, L. Jofre, and G. Peronnet, “On the Possible Use of Microwave-Active Imaging for Remote Thermal Sensing,” IEEE Transactions on Microwave Theory and Techniques, vol. 31, no. 9, pp. 777–781, Sep. 1983.

S. Y. Semenov et al., “Microwave tomography: two-dimensional system for biological imaging,” IEEE Transactions on Biomedical Engineering, vol. 43, no. 9, pp. 869–877, Sep. 1996.

D. Li, P. M. Meaney, and K. D. Paulsen, “Conformal microwave imaging for breast cancer detection,” IEEE Transactions on Microwave Theory and Techniques, vol. 51, no. 4, pp. 1179–1186, Apr. 2003.

Q. Fang, P. M. Meaney, S. D. Geimer, A. V. Streltsov, and K. D. Paulsen, “Microwave image reconstruction from 3-D fields coupled to 2-D parameter estimation,” IEEE Transactions on Medical Imaging, vol. 23, no. 4, pp. 475–484, Apr. 2004.

E. J. Bond, X. Li, S. C. Hagness, and B. D. Van Veen, “Microwave imaging via spacetime beamforming for early detection of breast cancer,” IEEE Transactions on Antennas and Propagation, vol. 51, no. 8, pp. 1690–1705, Aug. 2003.

W. C. Chew and Y. M. Wang, “Reconstruction of two-dimensional permittivity distribution using the distorted Born iterative method,” IEEE Transactions on Medical Imaging, vol. 9, no. 2, pp. 218–225, Jun. 1990.

S. Caorsi, G. L. Gragnani, and M. Pastorino, “Two-dimensional microwave imaging by a numerical inverse scattering solution,” IEEE Transactions on Microwave Theory and Techniques, vol. 38, no. 8, pp. 981–989, Aug. 1990.

C. Estatico, M. Pastorino, and A. Randazzo, “A Novel Microwave Imaging Approach Based on Regularization in Lp Banach Spaces,” IEEE Transactions on Antennas and Propagation, vol. 60, no. 7, pp. 3373–3381, Jul. 2012.

P. Lu, J. Córcoles, and P. Kosmas, “Nonlinear Microwave Imaging Using Fast Iterative Shrinkage Thresholding,” in 2019 Photonics & Electromagnetics Research Symposium - Spring (PIERS-Spring), 2019, pp. 1949–1956.

M. Hopfer, R. Planas, A. Hamidipour, T. Henriksson, and S. Semenov, “Electromagnetic Tomography for Detection, Differentiation, and Monitoring of Brain Stroke: A Virtual Data and Human Head Phantom Study,” IEEE Antennas and Propagation Magazine, vol. 59, no. 5, pp. 86–97, Oct. 2017.

A. Goetzke-Pala, A. Hoła, and Ł. Sadowski, “A non-destructive method of the evaluation of the moisture in saline brick walls using artificial neural networks,” Archives of Civil and Mechanical Engineering, vol. 18, no. 4, pp. 1729–1742, Sep. 2018.

Z. Wu and H. Wang, “Microwave Tomography for Industrial Process Imaging: Example Applications and Experimental Results,” IEEE Antennas and Propagation Magazine, vol. 59, no. 5, pp. 61–71, Oct. 2017.

D. Basu and K. Purkait, “A Hypothetical Analysis to Study the Variations of Complex Dielectric Permittivity for Detection of Various Stages of Cancer of a Biological Target using Microwave Tomography,” in 2019 Devices for Integrated Circuit (DevIC), 2019, pp. 433–440.

Z. Vilagosh, A. Lajevardipour, D. Appadoo, S. Juodkazis, and A. W. Wood, “Using Attenuated Total Reflection (ATR) Apparatus to Investigate the Temperature Dependent Dielectric Properties of Water, Ice, and Tissue-Representative Fats,” Applied Sciences, vol. 11, no. 6, 2021, Art. no. 2544.

T. Saito, H. Asano, H. Saito, R. Kita, N. Shinyashiki, and S. Yagihara, “Effects of Blood Stream on Non-Invasive Dielectric Spectroscopy Measurements for Biological Tissues,” Transactions of the Materials Research Society of Japan, vol. 45, no. 4, pp. 149–152, 2020.

D. A. Pollacco, L. Farina, P. S. Wismayer, L. Farrugia, and C. V. Sammut, “Characterization of the dielectric properties of biological tissues and their correlation to tissue hydration,” IEEE Transactions on Dielectrics and Electrical Insulation, vol. 25, no. 6, pp. 2191–2197, Dec. 2018.

X. Li, F. Yang, and B. Rubinsky, “A Correlation Between Electric Fields That Target the Cell Membrane Potential and Dividing HeLa Cancer Cell Growth Inhibition,” IEEE Transactions on Biomedical Engineering, vol. 68, no. 6, pp. 1951–1956, Jun. 2021.

K. Zhu, N. R. Hum, B. Reid, Q. Sun, G. G. Loots, and M. Zhao, “Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis,” Scientific Reports, vol. 10, no. 1, 2020, Art. no. 8712.

Y. Zhou, D. Yang, Y. Zhou, B. L. Khoo, J. Han, and Y. Ai, “Characterizing Deformability and Electrical Impedance of Cancer Cells in a Microfluidic Device,” Analytical Chemistry, vol. 90, no. 1, pp. 912–919, 2018.

A. Gupta and G. U. Kharat, “Modeling of Dielectric Properties of Cancer Cell and Evaluation of Cancer Stages: A Review,” International Journal of Recent Scientific Research, vol. 5, no. 2, pp. 443–448, Feb. 2014.

Z. Wei and X. Chen, “Induced-Current Learning Method for Nonlinear Reconstructions in Electrical Impedance Tomography,” IEEE Transactions on Medical Imaging, vol. 39, no. 5, pp. 1326–1334, May 2020.

D. Basu and K. Purkait, “Dynamic Nature of Electric Field Variations with Changing Dielectric Constant of Propagating Medium,” Journal of Electrical Engineering, Electronics, Control and Computer Science, vol. 6, no. 9, pp. 1–6, 2020.

D. Basu and K. Purkait, “Analysis of Narrow Beamwidth Microwave Scanning Techniques of Biological Targets Using Dipole Array Antenna,” in Intelligent Techniques and Applications in Science and Technology (Learning and Analytics in Intelligent Systems, vol. 12), S. Dawn, V. Balas, A. Esposito, and S. Gope, Eds. Cham, Switzerland: Springer Nature, 2020, pp. 383–393.