Targeted Therapy in Liver Tumor: Study on Nanoparticle Assisted with Porous Liver Model

  • Suchai Pongpakpien Department of Mechanical Engineering, Faculty of Engineering, Thammasat University, Pathum Thani 12120, Thailand
  • Niti Shaichompu Department of Mechanical Engineering, Faculty of Engineering, Thammasat University, Pathum Thani 12120, Thailand
  • Phadungsak Rattanadecho Department of Mechanical Engineering, Faculty of Engineering, Thammasat University, Pathum Thani 12120, Thailand
Keywords: Porous liver model, Microwave ablation, Nano assisted, Thermal conductivity, Electrical conductivity

Abstract

The high performance of Microwave ablation (MWA) is measured by the successful coagulate of the target tissues with less effect on the surrounding healthy tissues. To achieve this goal, the precious porous liver model is used for simulation to investigate how the performance improves when two key properties, thermal and electrical conductivity, have been changed. The investigation of selected nanoparticle, Carbon Nanotube (CNT), also has been included. The result has shown that increased thermal and electrical conductivity of target tissue in the porous liver promotes a higher heating rate and lower maximum temperature when compared with the normal porous liver tissue condition. The MWA performance improved when the selected nanoparticle CNT was included, producing an improved lesion shape with a short tail when compared with normal tissues. In summary, this study gives the necessary aspect for knowledge of enhancing the MWA process and can be used as a guideline to enhance the MWA efficacy.

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Published
2021-06-25
How to Cite
Pongpakpien, S., Shaichompu, N., & Rattanadecho, P. (2021). Targeted Therapy in Liver Tumor: Study on Nanoparticle Assisted with Porous Liver Model. Science & Technology Asia, 26(2), 87-98. Retrieved from https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/240302
Section
Engineering