Mixed Amodiaquine-Acetylsalicylic Acid Metal Complexes: Characterization and Antimicrobial Potentials

  • Mercy O. Bamigboye Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin 1515, Nigeria
  • Ikechukwu P. Ejidike Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Florida 1709, South Africa, Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Lagos 100212, Nigeria
  • Mistura Lawal Department of Pure and Applied Chemistry, Kebbi State University of Science and Technology, Aliero 1144, Nigeria
  • Ginikachukwu G. Nnabuike Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin 1515, Nigeria
  • Hadley S. Clayton Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Florida 1709, South Africa
Keywords: Amodiaquine, Physicochemical, Acetylsalicylic acid, Metal complexes, Antibacterial

Abstract

Series of new mixed Amodiaquine and Acetylsalicylic acid ligand donors with some transition metals in the mole ratio 1:1:1, lead to the formation of compound type: [M(AMQ)(ASA)], where M = Co(II), Ni(II), Zn(II), and Cu(II) ions. The complexes were characterized to understand the nature of the metal bonding to the free ligands. The geometry of the synthesized complexes was proposed based on their properties and spectroscopic techniques: melting point, ultraviolet-visible, infrared, molar conductance, elemental analysis and atomic absorption spectroscopic. The compounds were found to be in a tetrahedral environment for zinc complex, and copper in square planar geometry. Based on the molar conductivities, it was observed that the as-synthesized compounds were non-electrolytic in nature. The as-synthesized complexes were screened against some isolated organisms: B. Subtilis, K. Pneumonia, E. coli, P. aeruginosa, and S. aureus. It was observed that the complexes exhibited better activities than the free ligands. [Zn(AMQ)(ASA)] complex possessed the highest zone of inhibition (49 mm) at 40 μl/ml against E. coli strains.

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Published
2021-03-16
How to Cite
Bamigboye, M. O., Ejidike, I. P., Lawal, M., Nnabuike, G. G., & Clayton, H. S. (2021). Mixed Amodiaquine-Acetylsalicylic Acid Metal Complexes: Characterization and Antimicrobial Potentials. Science & Technology Asia, 26(1), 53-63. Retrieved from https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/240635
Section
Physical sciences