Mixed Amodiaquine-Acetylsalicylic Acid Metal Complexes: Characterization and Antimicrobial Potentials

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Published: Mar 16, 2021
Keywords:
Amodiaquine Physicochemical Acetylsalicylic acid Metal complexes Antibacterial

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Mercy O. Bamigboye
Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin 1515, Nigeria
Ikechukwu P. Ejidike
Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Florida 1709, South Africa, Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Lagos 100212, Nigeria
Mistura Lawal
Department of Pure and Applied Chemistry, Kebbi State University of Science and Technology, Aliero 1144, Nigeria
Ginikachukwu G. Nnabuike
Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin 1515, Nigeria
Hadley S. Clayton
Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Florida 1709, South Africa

Abstract

Series of new mixed Amodiaquine and Acetylsalicylic acid ligand donors with some transition metals in the mole ratio 1:1:1, lead to the formation of compound type: [M(AMQ)(ASA)], where M = Co(II), Ni(II), Zn(II), and Cu(II) ions. The complexes were characterized to understand the nature of the metal bonding to the free ligands. The geometry of the synthesized complexes was proposed based on their properties and spectroscopic techniques: melting point, ultraviolet-visible, infrared, molar conductance, elemental analysis and atomic absorption spectroscopic. The compounds were found to be in a tetrahedral environment for zinc complex, and copper in square planar geometry. Based on the molar conductivities, it was observed that the as-synthesized compounds were non-electrolytic in nature. The as-synthesized complexes were screened against some isolated organisms: B. Subtilis, K. Pneumonia, E. coli, P. aeruginosa, and S. aureus. It was observed that the complexes exhibited better activities than the free ligands. [Zn(AMQ)(ASA)] complex possessed the highest zone of inhibition (49 mm) at 40 μl/ml against E. coli strains.

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How to Cite
Bamigboye, M. O. ., Ejidike, I. P. ., Lawal, M. ., Nnabuike, G. G. ., & Clayton, H. S. . (2021). Mixed Amodiaquine-Acetylsalicylic Acid Metal Complexes: Characterization and Antimicrobial Potentials. Science & Technology Asia, 26(1), 53–63. Retrieved from https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/240635
Issue
Vol.26 No.1 (January-March 2021)
Section
Physical sciences