A Preliminary Study on the Effects of Vitexin on the Promotion of Hair Growth in Mice

Authors

  • Rueangrit Siriphanit Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Jitlada Meephansan Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Pinyadapat Areerob Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Werayut Yingmema Laboratory Animal Centers, Thammasat University, Pathum Thani 12120, Thailand
  • Raksawan Deenonpoe Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
  • Hok Bing Thio Department of Dermatology, Erasmus University Medical Center, Rotterdam 3015, Netherland

Keywords:

Androgenetic alopecia, Hair growth, Minoxidil, Mouse model, Vitexin

Abstract

In this study, the hair-growth-promoting effects of topical vitexin were compared with those of topical minoxidil in a mouse model. Six-week-old male C57BL/6 mice were randomly treated with 0.2% vitexin, 5% minoxidil, or 60% ethanol as a control. Topical application of
vitexin did not result in a significant difference of hair regrowth among groups. In contrast, histopathological data showed an increase in the number of hair follicles for the vitexin-treated group, with an accumulation in the early anagen phase in the dermis. The minoxidil-treated group showed a predominance of late anagen phase in the deep dermis and hypodermis, with some newly formed capillaries and vessel dilation. The hair-growth-promoting effects of vitexin were not significantly different from those of minoxidil. Importantly, vitexin slowly promoted anagen phase but did not induce systemic side effects. This study helps the development of a new therapeutic option for non-scarring alopecia.

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Published

2022-09-28

How to Cite

Rueangrit Siriphanit, Jitlada Meephansan, Pinyadapat Areerob, Werayut Yingmema, Raksawan Deenonpoe, & Hok Bing Thio. (2022). A Preliminary Study on the Effects of Vitexin on the Promotion of Hair Growth in Mice. Science & Technology Asia, 27(3), 260–267. Retrieved from https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/247452

Issue

Section

Biological sciences