Antibiofilm Activities of Quercetin on ESKAPE Pathogens: An in-silico Analysis
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Abstract
The treatment of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) is difficult due to their antibiotic resistance, which is mostly attributed to the biofilm matrices produced by these bacteria. These biofilms are notoriously difficult to counter though some natural compounds show promise. Quercetin, a plant-derived flavanol is found to have antibiofilm activities against these ESKAPE pathogens. In this study, molecular docking experiments demonstrated a strong affinity between quercetin and biofilm forming proteins of ESKAPE pathogens, namely 3TIP, 3ZYB, 5KED, 5FCE, 5D6H and 6YF6, which indicates that quercetin could be effective for eradicating ESKAPE pathogens. Optimization of parameters for best molecular interaction was studied using Box Behnken Response Surface Methodology.
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