In Silico Identification of Bajakah Root (Spatholobus littoralis Hassk) Alkaloid Compounds to Stimulate Lipolysis Through Inhibition of Phosphodiesterase-4
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Abstract
Modulating the nucleotide cycle signaling of phosphodiesterases (PDEs) can facilitate thermogenesis. When it comes to obesity therapy, utilizing herbs as part of non-pharmacological treatment methods is highly recommended due to the lower risks involved compared to pharmacological methods. Bajakah root, a typical plant found in West Kalimantan, also known by its Latin name, Spatholobus littoralis Hassk (S. littoralis Hassk), is currently being extensively researched. Isorhynchophylline and rhynchophylline are common alkaloids found in S. littoralis Hassk. The objective of this study was to explore the potential of these two alkaloids through an in silico approach. Chem3D Pro software was used to prepare ligands with energy conformations for accurate docking results via AutoDock Vina software. The visualization was carried out in Biovia Discovery Studio. The lowest binding energy values were obtained for the PDE4C isoform, with values of -9.14, -7.61, and -5.61 kcal/mol, respectively. The interaction between isorhynchophylline and PDE4C had the lowest binding energy. In silico studies suggest that two alkaloid components, isorhynchophylline and rhynchophylline, found in S. littoralis Hassk have the potential to increase lipolysis activity.
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