Comparison of automated blood cell counting of breast cancer patients by Advia 120 and Sysmex XT 4000i

Abstract

Breast cancer is one of the most common diseases found among women in Thailand. The disease is usually treated with surgery which may be followed by chemotherapy or radiation therapy, or both. During the treatment, complete blood counts (CBC) of the patients are important for follow-up and evaluation of the status of the patients. In this aspect, there might  be  certain CBC parameters which were affected by hematology analyzers.  At present, Advia 120 and Sysmex XT 4000i routinely used in various hematology laboratories quantification of each parameter by these two analyzers is. Therefore, the aim of this study was to compare and to analyze the correlation between various parameters determined by Advia 120 and Sysmex XT 4000i.  One hundred EDTA blood samples from breast cancer patients at Mahavajiralongkorn Cancer Center were tested by Sysmex XT 4000i and Advia 120.  Among the 100 subjects in the study, eighty-nine patients had non-metastases and eleven patients had metastases. They were treated by radiation and/or chemotherapy. The Student’s t-test and Pearson correlation coefficient were tested by using SPSS 17.0.  The tested results were compared among the parameters determined by Advia 120 and Sysmex XT 4000i in the samples of the patients with breast cancer.

   The correlation was found in thirteen parameters of Advia 120 and Sysmex XT 4000i in 100 patients with breast cancer with the means correlation coefficients (r) of 0.96.  In conclusion, the thirteen parameters were acceptable, no significant bias, and good correlation.  The accuracy and precision in most tested parameters Sysmex XT 4000i and Advia 120 were satisfactory in the patients with breast cancer

Keywords: Automated hematology analyzer; breast cancer; Sysmex XT 4000i and Advia 120