Outcomes of Antimicrobial Discontinuation Following Guidelines in Patients with Hospital-acquired Pneumonia

  • Pavaruch Sangmuang นักศึกษา หลักสูตรเภสัชศาสตรมหาบัณฑิต สาขาวิชาเภสัชกรรมคลินิก คณะเภสัชศาสตร์ มหาวิทยาลัยเชียงใหม่ และ เภสัชกรชำนาญการ กลุ่มงานเภสัชกรรม โรงพยาบาลเชียงคำ อ.เชียงคำ จ.พะเยา
  • Aroonrut Lucksiri อาจารย์ ภาควิชาบริบาลเภสัชกรรม คณะเภสัชศาสตร์ มหาวิทยาลัยเชียงใหม่
  • Wasan Katip ผู้ช่วยศาสตราจารย์ ภาควิชาบริบาลเภสัชกรรม คณะเภสัชศาสตร์ มหาวิทยาลัยเชียงใหม่
Keywords: Hospital-acquired pneumonia, Antimicrobial discontinuation guidelines, Recurrence rate


The objective of this study was to compare recurrence rates of hospital-acquired pneumonia (HAP) between the group discontinued antimicrobials within 48 hours after their clinical conditions met all the criteria in the antimicrobial discontinuation guidelines (study group) and the group of antimicrobials continuing (control group). Data of the patients admitted to Chiang Kham hospital, Phayao province between January 1, 2013 and June 30, 2016 were collected retrospectively. The clinical conditions in the antimicrobial discontinuation guidelines included 1) body temperature 2) oxygen saturation in peripheral blood 3) characteristics of sputum 4) signs and symptoms of pneumonia. From 181 HAP patients, there were 77 patients whom their clinical data were available for the evaluation according to the guidelines. Most of the patients had late onset HAP. The study demonstrated that recurrence rate of pneumonia was 5.1% (2 from 39 patients) in the study group and 7.9% (3 from 38 patients) in the control group. Due to limited number of patients in the study, the non-inferiority of recurrence rate between study and control groups could not be clearly concluded.


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