Fluorescent Micellar Sensor for Long-Chain Aldehydes Detection
Keywords:
Long-chain aldehydes, Micelle, FluorescenceAbstract
Long-chain aldehyde compounds are regarded as potential biomarkers of many diseases for biomedical applications. Apart from hydrophobic tails of long-chain hydrocarbon and formyl group of long-chain aldehydes, it should perform as surfactants to form the self-assembling organized micelles. In this research, the HZ-doped micellar probes towards aldehyde have been achieved in the concept of incomplete micelle, which was prepared by CTAB and co-surfactant (S1) upon the challenge optimizing task. The micelles could form the complete micelle by long-chain aldehyde as a target analyte based on a self-assembling organized nanomicelles. The fluorescence intensity of fluorescent dye incorporated in incomplete micelle was enhanced upon the addition of long-chain aldehyde to form the complete micelles. Moreover, the fluorescence change of dye-doped micelles is proportional to the amount of long-chain aldehyde added with the limit of detection (LOD) of 80.38 µM in the linear concentration range of 0.03 to 0.33 mM in 2.5% DMSO/PBS buffer pH 7.4.
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11. Liu JF, Yuan BF, Feng YQ. Determination of hexanal and heptanal in human urine using magnetic solid phase extraction coupled with in-situ derivatization by high performance liquid chromatography. Talanta. 2015; 136: 54-59.
12. Liu C, Shi C, Li H, Du W, Li Z, Wei L, Yu M. Nanomolar fluorescent quantitative detection of formaldehyde with a 8-hydroxyquinoline derivative in aqueous solution and electrospun nanofibers. Sensors and Actuators B: Chemical. 2015; 219: 185-191.
13. Tang Y, Kong X, Liu ZR, Xu A, Lin W. Lysosome-targeted turn-on fluorescent probe for endogenous formaldehyde in living cells. Analytical Chemistry. 2016; 88 (19): 9359-9363.
14. Mukherjee K, Chio TI, Gu H, Banerjee A, Sorrentino AM, Sackett DL, Bane SL. Benzocoumarin hydrazine: A large stokes shift fluorogenic sensor for detecting carbonyls in isolated biomolecules and in live cells. ACS Sensors. 2017; 2 (1): 128-134.
15. Sara M, M., M. O.; P., T. V. Applications of polymer micelles for imaging and drug delivery. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2015; 7 (5): 691-707.
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17. Tadros TF. Future developments in cosmetic formulations. International Journal of Cosmetic Science. 1992; 14 (3): 93-111.
18. Ding L, Bai Y, Cao Y, Ren G, Blanchard GJ, Fang Y. Micelle-induced versatile sensing behavior of bispyrene-based fluorescent molecular sensor for picric acid and PYX explosives. Langmuir. 2014; 30 (26): 7645-7653.
19. Oh T, Choi JY, Heller MJ. Enhanced fluorescent resonant energy transfer of DNA conjugates complexed with surfactants and divalent metal ions. Analyst. 2016; 141 (8): 2371-2375.
20. Yan F, Su B. Tailoring Molecular Permeability of Nanochannel-Micelle Membranes for Electrochemical Analysis of Antioxidants in Fruit Juices without Sample Treatment. Analytical Chemistry. 2016; 88(22): 11001-11006.
