Quality Evaluation of Commercial Thatbunjob Formulations in Thailand
Keywords:
Herbal medicine, Thatbunjob, Quality controlAbstract
Thatbunjob (TBJ) is a Thai traditional remedy comprising twenty-two herbs on the national list of essential medicines for alleviating symptoms such as diarrhea, indigestion, and abdominal discomfort. Its availability extends across various pharmaceutical presentations, including boluses, capsules, and powdered forms. Until now, there has been no investigation into the quality of TBJ products. This study aimed to examine the physicochemical properties, chemical contaminants, and microbial contamination in TBJ products, adhering to Thai herbal pharmacopeia guidelines and comparing them with in-house TBJ formulations. The findings indicated that a total of 7 samples had total ash content higher than the standard, with an average of 6.17-9.89 percent by weight. The extract amounts of both ethanol and water were lower than the criteria, with averages of 0.22-0.60 and 12.98-17.93 percent by weight, respectively. Additionally, microbial contamination exceeding the standard was found in 3 samples. These insights may contribute to refining production processes to ensure the practicality and safety of herbal composite drugs for future consumers.
References
Ministry of Public Health, private sector and government organization. National master plan of Thai herbal medicine development 1st issue between 2017-2021. Samut Prakan: TS Interprint Company Limited; 2016. Thai.
National Drug Information. Report of national drug system development A.D.2014 [Internet]. 2014 [updated 2014Dec01; cited 2023 Nov01]. Available from: https://ndi.fda.moph.go.th/ndi_policy/detail/66/%E0%B8%9C%E0%B8%A5%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%94%E0%B8%B3%E0%B9%80%E0%B8%99%E0%B8%B4%E0%B8%99%E0%B8%87%E0%B8%B2%E0%B8%99. Thai.
National Drug System Development Committee. National drug list of herbal medicine A.D.2023. Bangkok: Thai Government Gazette; 2023. p. 45-69. Thai.
Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol. 2005; 11(42): 6662-666.
Al-Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Rafatullah S, Qureshi S. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol. 2006; 22(1): 64-69.
Banerjee D, Maity B, Nag SK, Bandyopadhyay SK, Chattopadhyay S. Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. BMC Complement Altern Med. 2008; 8: 3.
Cho CH, Mei QB, Shang P, Lee SS, So HL, Guo X, et al. Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats. Planta Med. 2000; 66(4): 348-351.
Sahoo HB, Sahoo SK, Sarangi SP, Sagar R, Kori ML. Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats. Pharmacognosy Res. 2014; 6(3): 204-209.
Sheng Z, Yan X, Zhang R, Ni H, Cui Y, Ge J, et al. Assessment of the antidiarrhoeal properties of the aqueous extract and its soluble fractions of Chebulae Fructus (Terminalia chebula fruits). Pharm Biol. 2016; 54(9): 1847-1856.
Izadpanah S, Abdolghaffari AH, Farjadmand F, Eftekhari M, Baeeri M, Rahimifard M, et al. Beneficial effects of Trachyspermum ammi (L.) sprague on rat irritable bowel syndrome. Res J Pharmacogn. 2019; 6(2): 57-66.
Lee MS, Lee J, Kim Y. Green tea extract containing Piper retrofractum fruit ameliorates DSS-induced colitis via modulating microRNA-21 expression and NF-κB activity. Nutrients. 2022; 14(13). 2684.
Qu L, Liu C, Ke C, Zhan X, Li L, Xu H, et al. Atractylodes lancea rhizoma attenuates DSS-induced colitis by regulating intestinal flora and metabolites. Am J Chinese Med. 2022; 50(2): 525-552.
Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 2013; 4(6): 845-855.
Ahmad T, Shinkafi TS, Routray I, Mahmood A, Ali S. Aqueous extract of dried flower buds of Syzygium aromaticum inhibits inflammation and oxidative stress. J Basic Clin Pharm. 2012; 3(3): 323-327.
Wang Q, Li Y, Wang S, Xiang Z, Dong W, Li X, et al. A review of the historical records, chemistry, pharmacology, pharmacokinetics and edibility of Angelica dahurica. Arab J Chem. 2023; 16(8): 104877.
Jaiarree N, Itharat A, Suthon P, Panthong S. Anti-inflammatory, anti-bacterial and antioxidant activities of Thai medicinal plants for diarrheal treatment. Planta Med. 2013; 79(13): PN47.
Chaiyawat C, Jamtaweekul J, Wongpentak S, Inthongkaew P. Safety of herbal medicines in the National List of Essential Medicines. Bull Dept Med Sci. 2014; 56(3); 123-134. Thai.
Hutton M. Human health concerns of lead, mercury, cadmium and arsenic. In: Hutchinson TC, Meema KM, eds. Lead, Mercury, Cadmium and Arsenic in the Environment. New York: Wiley; 1987:53-68.
Tropea A. Microbial contamination and public health: an overview. Int J Environ Res Public Health. 2022;19(12):7441.
Bureau of Drug and Narcotic Department of Medical Sciences, Ministry of Public Health. Thai Herbal Pharmacopoeia 2021. Nonthaburi: Department of Medical Sciences, Ministry of Public Health; 2023. Thai.
Department of Thai Traditional and Alternative Medicine Ministry of Public Health. Thai Herbal Preparation Pharmacopoeia. Nonthaburi: Department of Thai Traditional and Alternative Medicine Ministry of Public Health; 2022. Thai.
Rao Y, Xiang B. Determination of total ash and acid-insoluble ash of Chinese herbal medicine Prunellae Spica by near infrared spectroscopy. Yakugaku Zasshi. 2009; 129(7): 881-886.
Dhaliwal SS, Sharma V, Shukla AK, Kaur M, Verma V, Sandhu PS, et al. Biofortification of oil quality, yield, and nutrient uptake in Indian mustard (Brassica juncea L.) by foliar application of boron and nitrogen. Front Plant Sci. 2022; 13: 976391.
Chua LY, Chong CH, Chua BL, Figiel A. Influence of drying methods on the antibacterial, antioxidant and essential oil volatile composition of herbs: A review. Food Bioprocess Technol. 2019; 12: 450-476.
World Health Organization. WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. Geneva, Switzerland: Press; 2007.
Pongmuangmul S, Jittaprasatsin C, Wangroongsarb P, Poolsawat L. Thailand’s Situation of Microbial Contamination in Traditional and Herbal Medicines in 2021. Bull Dept Med Sci.2023; 65 (2): 45-67. Thai.
Pascual ME, Carretero ME, Slowing KV, Villar A. Simplified screening by TLC of plant drugs. Pharm Biol. 2002; 40(2): 139-143.
Phayom T. Editorial: Botanicals of Current Interest. Thai J. Pharm. Sci. 1987;12(1): Article 1. Available from: https://digital.car.chula.ac.th/tjps/vol12/iss1/1. Thai.
Xu C, Zhang Y, Zhu L, Huang Y, Lu J. Influence of growing season on phenolic compounds and antioxidant properties of grape berries from vines grown in subtropical climate. J Agric Food Chem. 2011; 59(4): 1078-1086.
Thamma N, Anywat-napong W, Thongprayoon W, Luepong P, Anywatnapong M. The influence of ai marketing technology on online purchasing decisions of household consumers in Thailand. JDBS. 2023; 9(1): 1-18.
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