Itaconic Acid: A Promising and Sustainable Platform Chemical?
Article Sidebar
Published:
Jun 14, 2019
Keywords:
Itaconic acid Biorefinery Manufacturing Platform chemicals
Main Article Content
Abstract
Due to the increasing demand and focus for sustainable chemicals and fuels that are independent from fossil resources, itaconic acid gained interest and recognized for market position as a potential bio-based platform chemical. Itaconic acid can be produced via a chemical pathway or a biotechnological pathway, the more effective production way is the latter one, which is currently conducted in industrial scale production. In order to replace fossil-based chemicals, the efficiency of the current production that is mainly operated by using Aspergillus terreus has to be improved to achieve the economically feasible process. The recent progress in understanding the biosynthesis pathway, finding new raw materials and microbes as well as applying a more effective downstream process, facilitated the optimization of existing processes and resulted in reduction of production cost. However, there is still need for further optimization to achieve higher final concentrations and to use a broader range of low cost sustainable raw materials. Nowadays, the largest industrial producers of itaconic acid are located in China and the USA. If the production costs can be reduced and the downstream value chain for itaconic acid can be expanded, the market could be grow in the future.
Article Details
How to Cite
Sriariyanun, M., Heitz, J. H., Yasurin, P., Asavasanti, S., & Tantayotai, P. (2019). Itaconic Acid: A Promising and Sustainable Platform Chemical?. Applied Science and Engineering Progress, 12(2), 75–82. Retrieved from https://ph02.tci-thaijo.org/index.php/ijast/article/view/211252
Issue
Section
Review Articles
References
[1] M. Okabe, D. Lies, S. Kanamasa, and E. Y. Park, “Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus,” Applied Microbiology and Biotechnology, vol. 84, no. 4, pp. 597–606, 2009.
[2] S. Krull, A. Hevekerl, A. Kuenz, and U. Prüße, “Process development of itaconic acid production by a natural wild type strain of Aspergillus terreus to reach industrially relevant final titers,” Applied Microbiology and Biotechnology, vol. 101, no. 10, pp. 4063–4072, 2017.
[3] A. Kuenz and S. Krull, “Biotechnological production of itaconic acid-things you have to know,” Applied Microbiology and Biotechnology, vol. 102, no. 9, pp. 3901–3914, 2018.
[4] M. Carlsson, C. Habenicht, L. C. Kam, M. J. Antal, N. Bian, R. J. Cunningham, and M. Jones, “Study of the sequential conversion of citric to itaconic to methacrylic acid in near-critical and supercritical water,” Industrial & Engineering Chemistry Research, vol. 33, no. 8, pp. 1989–1996, 1994.
[5] T. Klement and J. Büchs, “Itaconic acid–a biotechnological process in change,” Bioresource Technology, vol. 135, pp. 422–431, 2013.
[6] K. Kinoshita, “Über die produktion von itaconsäure und mannit durch einen neuen schimmelpilz Aspergillus itaconicus,” Acta Phytochim, vol. 5, pp. 271–287, 1932.
[7] C. T. Calam, A. E. Oxford, and H. Raistrick, “Studies in the biochemistry of micro- organisms: Itaconic acid, a metabolic product of a strain of Aspergillus terreus Thom,” Biochemical Journal, vol. 33, no. 9, pp. 1488, 1939.
[8] A. Hevekerl, A. Kuenz, and K. D. Vorlop, “Influence of the pH on the itaconic acid production with Aspergillus terreus,” Applied Microbiology and Biotechnology, vol. 98, no. 24, pp. 10005–10012, 2014.
[9] B. C. Saha, G. J. Kennedy, N. Qureshi, and M. J. Bowman, “Production of itaconic acid from pentose sugars by Aspergillus terreus,” Biotechnology Progress, vol. 33, no. 4, pp. 1059–1067, 2017.
[10] M. G. Steiger, M. L. Blumhoff, D. Mattanovich, and M. Sauer, “Biochemistry of microbial itaconic acid production,” Frontiers in Microbiology, vol. 4, pp. 23, 2013.
[11] L. Regestein, T. Klement, P. Grande, D. Kreyenschulte, B. Heyman, T. Maßmann, A. Eggert, R. Sengpiel, Y. Wang, N. Wierckx, L. M. Blank, A. Spiess, W. Leitner, C. Bolm, M. Wessling, A. Jupke, M. Rosenbaum, and J. Büchs, “From beech wood to itaconic acid: Case study on biorefinery process integration,” Biotechnology for Biofuels, vol. 11, no. 1, pp. 279, 2018.
[12] A. Kuenz, Y. Gallenmüller, T. Willk, and K. D. Vorlop, “Microbial production of itaconic acid: Developing a stable platform for high product concentrations,” Applied Microbiology and Biotechnology, vol. 96, no. 5, pp. 1209–1216, 2012.
[13] T. Willke and K. D. Vorlop, “Biotechnological production of itaconic acid,” Applied Microbiology and Biotechnology, vol. 56, no. 3–4, pp. 289–295, 2001.
[14] K. Hegde, A. Prabhu, S. J. Sarma, S. K. Brar, and V. Dasu, “Potential applications of renewable itaconic acid for the synthesis of 3-methyltetrahydrofuran,” Platform Chemical Biorefinery, vol. 2016, pp. 181–200, 2017.
[15] A. A. El-Imam and C. Du, “Fermentative itaconic acid production,” Journal of Biodiverse Bioprocess Development, vol. 1, no. 119, pp. 2, 2014.
[16] N. Tippkötter, A. M. Duwe, S. Wiesen, T. Sieker, and R. Ulber, “Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids,” Bioresource Technology, vol. 167, pp. 447–455, 2014.
[17] X. Li, K. Zheng, C. Lai, J. Ouyang, and Q. Yong, “Improved itaconic acid production from undetoxified enzymatic hydrolysate of steamexploded corn stover using an Aspergillus terreus mutant generated by atmospheric and room temperature plasma,” BioResources, vol. 11, no. 4, pp. 9047–9058, 2016.
[18] C. S. K. Reddy and R. P. Singh, “Enhanced production of itaconic acid from corn starch and market refuse fruits by genetically manipulated Aspergillus terreus skr10,” Bioresource Technology, vol. 85, no. 1, pp. 69–71, 2002.
[19] X. Wu, Q. Liu, Y. Deng, J. Li, X. Chen, Y. Gu, X. Lv, Z. Zhang, S. Jiang, and X. Li, “Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus cicc40205 mutant,” Bioresource Technology, vol. 241, pp. 25–34, 2017.
[20] L. Dwiarti, M. Otsuka, S. Miura, M. Yaguchi, and M. Okabe, “Itaconic acid production using sago starch hydrolysate by Aspergillus terreus tn484-m1,” Bioresource Technology, vol. 98, no. 17, pp. 3329–3337, 2007.
[21] K. Yahiro, S. Shibata, S. R. Jia, Y. Park, and M. Okabe, “Efficient itaconic acid production from raw corn starch,” Journal of Fermentation and Bioengineering, vol. 84, no. 4, pp. 375–377, 1997.
[22] M. Petruccioli, V. Pulci, and F. Federici, Itaconic acid production by Aspergillus terreus on raw starchy materials,” Letters in Applied Microbiology, vol. 28, no. 4, pp. 309–312, 1999.
[23] T. Zambanini, H. H. Tehrani, E. Geiser, D. Merker, S. Schleese, J. Krabbe, J. M. Buescher, G. Meurer, N. Wierckx, and L. M. Blank, “Efficient itaconic acid production from glycerol with Ustilago vetiveriae TZ1,” Biotechnology for Biofuels, vol. 10, no. 1, pp. 131, 2017.
[24] J. Kim, H. M. Seo, S. K. Bhatia, H. S. Song, J. H. Kim, J. M. Jeon, K. Y. Choi, W. Kim, J. J. Yoon, Y. G. Kim, and Y. H. Yang, “Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cada) genes in Escherichia coli,” Scientific Reports, vol. 7, pp. 39768, 2017.
[25] N. Maassen, M. Panakova, N. Wierckx, E. Geiser, M. Zimmermann, M. Bölker, U. Klinner, and L. M. Blank, “Influence of carbon and nitrogen concentration on itaconic acid production by the smut fungus Ustilago maydis,” Engineering in Life Sciences, vol. 14, no. 2, pp. 129–134, 2014.
[26] A. Straathof, “The proportion of downstream costs in fermentative production processes,” in Comprehensive Biotechnology, 2nd ed. Amsterdam, Nederland: Elsevier, 2011, pp. 811–814.
[27] K. L. Wasewar, D. Shende, and A. Keshav, “Reactive extraction of itaconic acid using quaternary amine aliquat 336 in ethyl acetate, toluene, hexane, and kerosene,” Industrial & Engineering Chemistry Research, vol. 50, no. 2, pp. 1003–1011, 2010.
[28] Transparency Market Research. (2018, Nov.). Transparency Market Research 2015 itaconic acid market for synthetic latex, unsaturated polyester resins, detergents, super absorbent polymers (sap), and other applications - global industry analysis, size, share, growth, trends and forecast 2015–2023. Transparency Market Research, New York, USA [Online]. Available: https://www.transparencymarketresearch.com/itaconic-acid-market.html
[29] J. C. da Cruz, A. M. de Castro, and E. F. C. Sérvulo, “World market and biotechnological production of itaconic acid,” 3 Biotech, vol. 8, no. 3, pp. 138, 2018.
[30] J. Huang, L. Huang, J. Lin, Z. Xu, and P. Cen, “Organic chemicals from bioprocesses in china,” in Biotechnology in china II, Berlin, Germany: Springer, 2010, pp. 43–71.
[31] Global Market Insights. (2018, Nov.). Global Market Insights 2016 itaconic acid market size by application. Global Market Insights, Ohio, USA [Online]. Available: https://www.gminsights.com/industry-analysis/itaconic-acidmarket
[2] S. Krull, A. Hevekerl, A. Kuenz, and U. Prüße, “Process development of itaconic acid production by a natural wild type strain of Aspergillus terreus to reach industrially relevant final titers,” Applied Microbiology and Biotechnology, vol. 101, no. 10, pp. 4063–4072, 2017.
[3] A. Kuenz and S. Krull, “Biotechnological production of itaconic acid-things you have to know,” Applied Microbiology and Biotechnology, vol. 102, no. 9, pp. 3901–3914, 2018.
[4] M. Carlsson, C. Habenicht, L. C. Kam, M. J. Antal, N. Bian, R. J. Cunningham, and M. Jones, “Study of the sequential conversion of citric to itaconic to methacrylic acid in near-critical and supercritical water,” Industrial & Engineering Chemistry Research, vol. 33, no. 8, pp. 1989–1996, 1994.
[5] T. Klement and J. Büchs, “Itaconic acid–a biotechnological process in change,” Bioresource Technology, vol. 135, pp. 422–431, 2013.
[6] K. Kinoshita, “Über die produktion von itaconsäure und mannit durch einen neuen schimmelpilz Aspergillus itaconicus,” Acta Phytochim, vol. 5, pp. 271–287, 1932.
[7] C. T. Calam, A. E. Oxford, and H. Raistrick, “Studies in the biochemistry of micro- organisms: Itaconic acid, a metabolic product of a strain of Aspergillus terreus Thom,” Biochemical Journal, vol. 33, no. 9, pp. 1488, 1939.
[8] A. Hevekerl, A. Kuenz, and K. D. Vorlop, “Influence of the pH on the itaconic acid production with Aspergillus terreus,” Applied Microbiology and Biotechnology, vol. 98, no. 24, pp. 10005–10012, 2014.
[9] B. C. Saha, G. J. Kennedy, N. Qureshi, and M. J. Bowman, “Production of itaconic acid from pentose sugars by Aspergillus terreus,” Biotechnology Progress, vol. 33, no. 4, pp. 1059–1067, 2017.
[10] M. G. Steiger, M. L. Blumhoff, D. Mattanovich, and M. Sauer, “Biochemistry of microbial itaconic acid production,” Frontiers in Microbiology, vol. 4, pp. 23, 2013.
[11] L. Regestein, T. Klement, P. Grande, D. Kreyenschulte, B. Heyman, T. Maßmann, A. Eggert, R. Sengpiel, Y. Wang, N. Wierckx, L. M. Blank, A. Spiess, W. Leitner, C. Bolm, M. Wessling, A. Jupke, M. Rosenbaum, and J. Büchs, “From beech wood to itaconic acid: Case study on biorefinery process integration,” Biotechnology for Biofuels, vol. 11, no. 1, pp. 279, 2018.
[12] A. Kuenz, Y. Gallenmüller, T. Willk, and K. D. Vorlop, “Microbial production of itaconic acid: Developing a stable platform for high product concentrations,” Applied Microbiology and Biotechnology, vol. 96, no. 5, pp. 1209–1216, 2012.
[13] T. Willke and K. D. Vorlop, “Biotechnological production of itaconic acid,” Applied Microbiology and Biotechnology, vol. 56, no. 3–4, pp. 289–295, 2001.
[14] K. Hegde, A. Prabhu, S. J. Sarma, S. K. Brar, and V. Dasu, “Potential applications of renewable itaconic acid for the synthesis of 3-methyltetrahydrofuran,” Platform Chemical Biorefinery, vol. 2016, pp. 181–200, 2017.
[15] A. A. El-Imam and C. Du, “Fermentative itaconic acid production,” Journal of Biodiverse Bioprocess Development, vol. 1, no. 119, pp. 2, 2014.
[16] N. Tippkötter, A. M. Duwe, S. Wiesen, T. Sieker, and R. Ulber, “Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids,” Bioresource Technology, vol. 167, pp. 447–455, 2014.
[17] X. Li, K. Zheng, C. Lai, J. Ouyang, and Q. Yong, “Improved itaconic acid production from undetoxified enzymatic hydrolysate of steamexploded corn stover using an Aspergillus terreus mutant generated by atmospheric and room temperature plasma,” BioResources, vol. 11, no. 4, pp. 9047–9058, 2016.
[18] C. S. K. Reddy and R. P. Singh, “Enhanced production of itaconic acid from corn starch and market refuse fruits by genetically manipulated Aspergillus terreus skr10,” Bioresource Technology, vol. 85, no. 1, pp. 69–71, 2002.
[19] X. Wu, Q. Liu, Y. Deng, J. Li, X. Chen, Y. Gu, X. Lv, Z. Zhang, S. Jiang, and X. Li, “Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus cicc40205 mutant,” Bioresource Technology, vol. 241, pp. 25–34, 2017.
[20] L. Dwiarti, M. Otsuka, S. Miura, M. Yaguchi, and M. Okabe, “Itaconic acid production using sago starch hydrolysate by Aspergillus terreus tn484-m1,” Bioresource Technology, vol. 98, no. 17, pp. 3329–3337, 2007.
[21] K. Yahiro, S. Shibata, S. R. Jia, Y. Park, and M. Okabe, “Efficient itaconic acid production from raw corn starch,” Journal of Fermentation and Bioengineering, vol. 84, no. 4, pp. 375–377, 1997.
[22] M. Petruccioli, V. Pulci, and F. Federici, Itaconic acid production by Aspergillus terreus on raw starchy materials,” Letters in Applied Microbiology, vol. 28, no. 4, pp. 309–312, 1999.
[23] T. Zambanini, H. H. Tehrani, E. Geiser, D. Merker, S. Schleese, J. Krabbe, J. M. Buescher, G. Meurer, N. Wierckx, and L. M. Blank, “Efficient itaconic acid production from glycerol with Ustilago vetiveriae TZ1,” Biotechnology for Biofuels, vol. 10, no. 1, pp. 131, 2017.
[24] J. Kim, H. M. Seo, S. K. Bhatia, H. S. Song, J. H. Kim, J. M. Jeon, K. Y. Choi, W. Kim, J. J. Yoon, Y. G. Kim, and Y. H. Yang, “Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cada) genes in Escherichia coli,” Scientific Reports, vol. 7, pp. 39768, 2017.
[25] N. Maassen, M. Panakova, N. Wierckx, E. Geiser, M. Zimmermann, M. Bölker, U. Klinner, and L. M. Blank, “Influence of carbon and nitrogen concentration on itaconic acid production by the smut fungus Ustilago maydis,” Engineering in Life Sciences, vol. 14, no. 2, pp. 129–134, 2014.
[26] A. Straathof, “The proportion of downstream costs in fermentative production processes,” in Comprehensive Biotechnology, 2nd ed. Amsterdam, Nederland: Elsevier, 2011, pp. 811–814.
[27] K. L. Wasewar, D. Shende, and A. Keshav, “Reactive extraction of itaconic acid using quaternary amine aliquat 336 in ethyl acetate, toluene, hexane, and kerosene,” Industrial & Engineering Chemistry Research, vol. 50, no. 2, pp. 1003–1011, 2010.
[28] Transparency Market Research. (2018, Nov.). Transparency Market Research 2015 itaconic acid market for synthetic latex, unsaturated polyester resins, detergents, super absorbent polymers (sap), and other applications - global industry analysis, size, share, growth, trends and forecast 2015–2023. Transparency Market Research, New York, USA [Online]. Available: https://www.transparencymarketresearch.com/itaconic-acid-market.html
[29] J. C. da Cruz, A. M. de Castro, and E. F. C. Sérvulo, “World market and biotechnological production of itaconic acid,” 3 Biotech, vol. 8, no. 3, pp. 138, 2018.
[30] J. Huang, L. Huang, J. Lin, Z. Xu, and P. Cen, “Organic chemicals from bioprocesses in china,” in Biotechnology in china II, Berlin, Germany: Springer, 2010, pp. 43–71.
[31] Global Market Insights. (2018, Nov.). Global Market Insights 2016 itaconic acid market size by application. Global Market Insights, Ohio, USA [Online]. Available: https://www.gminsights.com/industry-analysis/itaconic-acidmarket