A Study on the Influence of Functionalized Graphene on the Mechanical and Biocompatibility Performance of Electrospun Polyvinyl Alcohol Nanocomposites
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Abstract
Polyvinyl alcohol (PVA), a synthetic polymer produced by polymerizing vinyl acetate and subjecting it to alkaline hydrolysis, exhibits properties such as film formation, emulsification, and adhesion. However, pure PVA’s biocompatibility and mechanical properties are limited. Its hydrophilicity also causes it to dissolve in water and blood, rendering it less suitable for drug delivery applications. To address these limitations, PVA was crosslinked with glutaraldehyde (GA) to enhance toughness and resistance to water and blood dissolution. Additionally, carboxyl (COOH) and hydroxyl (OH) functionalized graphene were incorporated into electrospun PVA nanocomposites to further improve their mechanical properties. The results show that adding COOH- and OH-functionalized graphene in four different concentrations (0.5, 1.0, 1.5, and 2.0 wt.%) significantly enhanced the mechanical characteristics of PVA nanocomposites. Tensile strength and Young's modulus increased substantially, with OH-functionalized graphene increasing tensile strength and Young's modulus by 224% and 338.3%, respectively, and COOH-functionalized graphene increasing these properties by 245.6% and 371.4%. Morphological characterization using FT-IR and FESEM confirmed the successful incorporation of graphene into the PVA matrix. Biocompatibility testing through APTT and PT assays showed both nanocomposites are biocompatible, suggesting their potential for biomedical applications. The optimal filler concentration for both graphene types was 1.5 wt.%. This research demonstrates the promising potential of innovative materials for healthcare and biomedical engineering applications.
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S. K. Palaniappan, M. K. Singh, S. M. Rangappa, and S. Siengchin, “Eco-friendly biocomposites: A step towards achieving sustainable development goals,” Composites, vol. 7, pp. 1–3, 2023.
J. Chen, Y. Li, Y. Zhang, and Y. Zhu, “Preparation and characterization of graphene oxide reinforced PVA film with boric acid as crosslinker,” Journal of Applied Polymer Science, vol. 132, no. 22, 2015, doi: 10.1002/ app.42000.
J. Jose, M. A. Al‐Harthi, M. A. A. AlMa'adeed, J. B. Dakua, and S. K. De, “Effect of graphene loading on thermomechanical properties of poly (vinyl alcohol)/starch blend,” Journal of Applied Polymer Science, vol. 132, no. 16, 2015, doi: 10.1002/app.41827.
R. Surudzic, A. Jankovic, M. Mitric, I. Matic, Z. D. Juranic, L. Zivkovic, V. Miskovic-Stankovic, K. Y. Rhee, S. J. Park, and D. Hui, “The effect of graphene loading on mechanical, thermal and biological properties of poly (vinyl alcohol)/ graphene nanocomposites,” Journal of Industrial and Engineering Chemistry, vol. 34, pp. 250–257, 2016.
J. Wang, X. Wang, C. Xu, M. Zhang, and X. Shang, “Preparation of graphene/poly (vinyl alcohol) nanocomposites with enhanced mechanical properties and water resistance,” Polymer International, vol. 60, pp. 816–822, 2011.
N. Georgieva, R. Bryaskova, and R. Tzoneva, “New Polyvinyl alcohol-based hybrid materials for biomedical application,” Materials Letters, vol. 88, pp. 19–22, 2012.
R. Phiri, S. M. Rangappa, S. Siengchin, and D. Marinkovic, “Agro-waste natural fiber sample preparation techniques for bio-composites development: Methodological insights,” Facta Universitatis, Series: Mechanical Engineering, vol. 21, pp. 631–656, 2023.
R. Eivazzadeh-Keihan, F. Radinekiyan, H. Madanchi, H. A. M. Aliabadi, and A. Maleki, “Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties,” Carbohydrate Polymers, vol. 248, 2020, Art. no. 116802.
M. A. Kanjwal and A. A. Ghaferi, “Graphene incorporated electrospun nanofiber for electrochemical sensing and biomedical applications: A critical review,” Sensors, vol. 22, p. 8661, 2022.
D. Nataraj, R. Reddy, and N. Reddy, “Crosslinking electrospun poly (vinyl) alcohol fibers with citric acid to impart aqueous stability for medical applications,” European Polymer Journal, vol. 124, 2020, Art. no. 109484.
J. W. Drexler and H. M. Powell, “Dehydrothermal crosslinking of electrospun collagen,” Tissue Engineering Part C: Methods, vol. 17, pp. 9–17, 2011.
X. Li, X. Yang, Z. Wang, Y. Liu, J. Guo, Y. Zhu, J. Shao, J. Li, L. Wang, and K. Wang, “Antibacterial, antioxidant and biocompatible nanosized quercetin-PVA xerogel films for wound dressing,” Colloids and Surfaces B: Biointerfaces, vol. 209, 2022, Art. no. 112175.
R. Gobi, P. Ravichandiran, R. S. Babu, and D. J. Yoo, “Biopolymer and synthetic polymer-based nanocomposites in wound dressing applications: A review,” Polymers, vol. 13, p. 1962, 2021.
I. Suyambulingam, S. M. Rangappa, and S. Siengchin, “Advanced materials and technologies for engineering applications,” Applied Science and Engineering Progress, vol. 16, pp. 6760–6760, 2023.
M. Koosha and H. Mirzadeh, “Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers,” Journal of Biomedical Materials Research Part A, vol. 103, pp. 3081–3093, 2015.
M. Aslam, M. A. Kalyar, and Z. A. Raza, “Fabrication of reduced graphene oxide nanosheets doped PVA composite films for tailoring their opto-mechanical properties,” Applied Physics A, vol. 123, pp. 1–12, 2017.
F. H. Falqi, O. A. Bin-Dahman, M. Hussain, and M. A. Al-Harthi, “Preparation of miscible PVA/PEG blends and effect of graphene concentration on thermal, crystallization, morphological, and mechanical properties of PVA/PEG (10 wt%) blend,” International Journal of Polymer Science, vol. 2018, no. 1, 2018, Art. no. 852793.
H. Adeli, M. T. Khorasani, and M. Parvazinia, “Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: Fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay,” International Journal of Biological Macromolecules, vol. 122, pp. 238–254, 2019.
Y.-H. Chien, M.-T. Ho, C.-H. Feng, J.-H. Yen, Y.-C. Chang, C.-S. Lai, and R.-F. Louh, “Fabrication of glutaraldehyde vapor treated PVA/SA/GO/ZnO electrospun nanofibers with high liquid absorbability for antimicrobial of Staphylococcus aureus,” Nanomaterials, vol. 13, p. 932, 2023.
C. Tang, C. D. Saquing, J. R. Harding, and S. A. Khan, “In situ cross-linking of electrospun poly (vinyl alcohol) nanofibers,” Macromolecules, vol. 43, pp. 630–637, 2010.
H. Tian, L. Yuan, J. Wang, H. Wu, H. Wang, A. Xiang, B. Ashok, and A. V. Rajulu, “Electrospinning of polyvinyl alcohol into crosslinked nanofibers: An approach to fabricate functional adsorbent for heavy metals,” Journal of hazardous Materials, vol. 378, 2019, Art. no. 120751.
Y.-s. Jun, S. Habibpour, M. Hamidinejad, M. G. Park, W. Ahn, A. Yu, and C. B. Park, “Enhanced electrical and mechanical properties of graphene nano-ribbon/thermoplastic polyurethane composites,” Carbon, vol. 174, pp. 305–316, 2021.
A. A. Iqbal, N. Sakib, A. P. Iqbal, and D. M. Nuruzzaman, “Graphene-based nanocomposites and their fabrication, mechanical properties and applications,” Materialia, vol. 12, 2020, Art. no. 100815.
X. Yang, L. Li, S. Shang, and X.-m. Tao, “Synthesis and characterization of layer-aligned poly (vinyl alcohol)/graphene nanocomposites,” Polymer, vol. 51, pp. 3431–3435, 2010.
S. Gahlot, P. P. Sharma, V. Kulshrestha, and P. K. Jha, “SGO/SPES-based highly conducting polymer electrolyte membranes for fuel cell application,” ACS Applied Materials and Interfaces, vol. 6, pp. 5595–5601, 2014.
C. Bao, Y. Guo, L. Song, and Y. Hu, “Poly (vinyl alcohol) nanocomposites based on graphene and graphite oxide: A comparative investigation of property and mechanism,” Journal of Materials Chemistry, vol. 21, pp. 13942–13950, 2011.
H. K. F. Cheng, N. G. Sahoo, Y. P. Tan, Y. Pan, H. Bao, L. Li, S. H. Chan, and J. Zhao, “Poly (vinyl alcohol) nanocomposites filled with poly (vinyl alcohol)-grafted graphene oxide,” ACS applied materials and Interfaces, vol. 4, pp. 2387–2394, 2012.
T. Cheng-an, Z. Hao, W. Fang, Z. Hui, Z. Xiaorong, and W. Jianfang, “Mechanical properties of graphene oxide/polyvinyl alcohol composite film,” Polymers and Polymer Composites, vol. 25, pp. 11–16, 2017.
Y. Wang, G. Yang, W. Wang, S. Zhu, L. Guo, Z. Zhang, and P. Li, “Effects of different functional groups in graphene nanofiber on the mechanical property of polyvinyl alcohol composites by the molecular dynamic simulations,” Journal of Molecular Liquids, vol. 277, pp. 261–268, 2019.
S. K. Jaganathan and M. P. Mani, “Electrospun polyurethane nanofibrous composite impregnated with metallic copper for wound-healing application,” 3 Biotech, vol. 8, p. 327, 2018.