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Problem-based learning can help to promote higher order thinking skills in students and nurture their analytical thinking and problem-solving ability. Participating in a self-directed and collaborative learning process helps them to develop systematic thinking skills. The purposes of this research were to 1) develop and validate the efficiency of online instruction and problem-based learning on an introduction to programming course and, 2) to study the analytical thinking ability of students before and after learning by this method. The sample group was undergraduate students at Nakhon Ratchasima Rajabhat University studying computer programming in the second semester of the 2018 academic year. The sample group was divided into one group was for finding out the efficiency of the lesson; it comprised 31 students and another group was 30 students for a purpose of making a comparison to find out the analytical thinking ability before and after they participated in teaching and learning activities based on the problem-based approach. Findings include: 1) the efficiency of activity knowledge is equal to 80.16/80.32 and 2) the level of analytical skills after learning is higher than it was before learning.
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