Antibacterial and Cytotoxic Activities of Rhodomyrtone Derivatives
Keywords:
Rhodomyrtone, Rhodomyrtone derivatives, Rhodomyrtus tomentosa, Anticancer, Antibacterial, AcylphloroglucinolsAbstract
Rhodomyrtone, a bioactive acylphloroglucinols compound, was obtained from the leaves of Rhodomyrtus tomentosa (Aiton.) Hassk and had been scientifically evidenced as multiple potential pharmacological activities. The purpose of research is to synthesize rhodomyrtone derivatives and evaluated for their antibacterial and anticancer activities. Rhodomyrtone derivatives 2-12 were synthesized and their structures were elucidated by spectroscopic techniques. The results indicated that rhodomyrtone showed antibacterial activity similar to that of a standard drug (vancomycin). It exhibited higher activity than derivatives. Rhodomyrtone (1) exhibited highest anticancer activity against H460 and PC3 cells with IC50 value of 6.12 and 13.30 mM. Whereas, derivatives 8 and 9 gave higher anticancer activity against HeLa cell than rhodomyrtone.
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