Hexane Extract of Seaweed Caulerpa lentillifera Inhibits Cell Proliferation and Induces Apoptosis of Human Glioblastoma Cells

  • Varitta Tanawoot Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand
  • Pornpun Vivithanaporn Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand
  • Tanapan Siangcham Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand
  • Krai Meemon Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
  • Nakorn Niamnont Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand
  • Prasert Sobhon Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
  • Montakan Tamtin Department of Fisheries, Phetcha Buri Coastal Aquaculture Research and Development Center, Phetcha Buri 76100, Thailand
  • Kant Sangpairoj Division of Anatomy, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand, Thammasat University Research Unit in Nutraceuticals and Food Safety, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
Keywords: Caulerpa lentillifera, Seaweed, Glioblastoma, Proliferation, Apoptosis

Abstract

Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.

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Published
2021-06-25
How to Cite
Tanawoot, V., Vivithanaporn, P., Siangcham, T., Meemon, K., Niamnont, N., Sobhon, P., Tamtin, M., & Sangpairoj, K. (2021). Hexane Extract of Seaweed Caulerpa lentillifera Inhibits Cell Proliferation and Induces Apoptosis of Human Glioblastoma Cells. cience & echnology sia, 26(2), 128-137. etrieved from https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/219342
Section
Biological sciences