Hexane Extract of Seaweed Caulerpa lentillifera Inhibits Cell Proliferation and Induces Apoptosis of Human Glioblastoma Cells

Varitta Tanawoot; Pornpun Vivithanaporn; Tanapan Siangcham; Krai Meemon; Nakorn Niamnont; Prasert Sobhon; Montakan Tamtin; Kant Sangpairoj

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เผยแพร่แล้ว: มิ.ย. 25, 2021

คำสำคัญ:

Caulerpa lentillifera, Seaweed, Glioblastoma, Proliferation, Apoptosis

Varitta Tanawoot

Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand

Pornpun Vivithanaporn

Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand

Tanapan Siangcham

Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand

Krai Meemon

Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Nakorn Niamnont

Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand

Prasert Sobhon

Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Montakan Tamtin

Department of Fisheries, Phetcha Buri Coastal Aquaculture Research and Development Center, Phetcha Buri 76100, Thailand

Kant Sangpairoj

Division of Anatomy, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand, Thammasat University Research Unit in Nutraceuticals and Food Safety, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand

บทคัดย่อ

Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.

รูปแบบการอ้างอิง

Tanawoot, V., Vivithanaporn, P., Siangcham, T., Meemon, K., Niamnont, N., Sobhon, P., … Sangpairoj, K. (2021). Hexane Extract of Seaweed Caulerpa lentillifera Inhibits Cell Proliferation and Induces Apoptosis of Human Glioblastoma Cells. Science & Technology Asia, 26(2), 128–137. สืบค้น จาก https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/219342

ฉบับ

Vol.26 No.2 (April-June 2021)

ประเภทบทความ

Biological sciences

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