Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Crude Boletus griseipurpureus, Corner Extracted
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Abstract
This research aimed to investigate the inhibitory effects of crude extracts of Samet mushrooms, an edible wild mushroom, on the enzymes alpha-amylase and alpha-glucosidase. These two enzymes play crucial roles in carbohydrate digestion within the digestive system. Inhibiting these enzymes is a strategy for managing diabetes, a metabolic disorder that results in elevated blood sugar levels. The Samet mushroom extracts used in this study were obtained using hexane, dichloromethane, and methanol as solvents. The results revealed that the crude extract from methanol exhibited the strongest inhibitory effects on alpha-amylase and alpha-glucosidase, with IC50 values of 0.082±0.01 mg/mL and 0.037±0.01 mg/mL, respectively. The methanol crude extract demonstrated significantly higher inhibitory activity compared to acarbose, a diabetes medication with an IC50 value of 4.8±1.00 mg/mL. This research highlights the potential of Samet mushrooms as a nutraceutical for the treatment of diabetes.
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