Nanoparticles for the Cancer Therapeutics
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Abstract
Nanoparticles have been gained more attention in biomedical applications particularly for the cancer therapeutics in order to enhance the therapeutic efficacy. Some of nanoparticles (e.g. Doxil and Abraxane) were already approved by US FDA for cancer treatments and some others have been investigated in clinical trials. Almost nanoparticles in curent cancer treatments penetrate and accumulate in the cancer cells by using the passive mechanism through the Enhanced permeability and retention (EPR) effect. In this article, the basic concepts of nanoparticles for drug delivery in cancer therapeutics are discussed. The chemical compositions, shapes, sizes, and surfaces (charge, area, and reactivity) of nanoparticles, which play a crucial role for applying nanoparticles in cancer treatments, are explained. In addition, the obstacles and the future trends of nanoparticle research for cancer therapeutics are discussed as well.
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