Antimicrobial Agents Produced by Fusarium sp., an Endophytic Fungus of Salvinia cuculata Roxb & Bory

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Wanrudee Hiranrat
Asadhawut Hiranrat
Preuttiporn Supaphon
Hiproheng Baha


Isolation of the chemical constituents from an endophytic fungus Fusarium sp. , isolated from
Salvinia cucullata Roxb. & Bory, yielded four compounds: “Sydoxanthone A (1)”, “13-O-acetylsydowinin B (2)”,
“Secalonic Acid A (3)” and “Emodin (4)”. Antimicrobial activity of isolated compounds against four bacteria,
S. aureus (SA), Methicillin - resistant S. aureus, P. aeruginosa ATCC27853 (MRSA SK1) and E. coli (EC)
and against two yeast, Candida albicans ATCC90028 (CA90028) and Cryptococcus neoformans ATCC90112
Flucytosine – resistant (CN90112) was determined. The results were found that compound 3 had good
antibacterial activity against SA, MRSA SK1, PA and EC and antiyeast activity against CA90028 and
CN90112 with the MIC 25.1, 25.1, 25.1, 50.2, 50.2 and 50.2 μ M, respectively. Compound 1 exhibited
moderate activities against bacteria SA, MRSA SK1 and PA at 82.2 μM. However compound 2 and 4 showed
weak activities to inhibit the growth of bacteria and yeast.


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