Total Flavonoid Content, Antioxidant Properties, and COX Inhibition of a Dual-Extract Herbal Blend: Formulation of a Gel for Anti-Inflammatory and Wound-Healing Applications

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Published: Aug 16, 2025
DOI: https://doi.org/10.55164/ajstr.v28i4.257666
Keywords:
Urtica dioica Angelica sinensis Flavonoid content Angelica sinensis polysaccharide Antioxidant activity Lipid peroxide inhibition Anti-inflammatory effects

Main Article Content

S Valarmathi
MGR Educational and Research institute, Velapanchavadi, Chennai-600077, India
Komal Kriti
Department of Pharmaceutical Sciences, Dhanbad College of Pharmacy and Research Institute, Near BBMKU, Shakti Nagar, Nag Nagar, Dhanbad, Jharkhand – 826004, India
Tabrej Mujawar
Department of Pharmacology, Gangamai College of Pharmacy, Nagaon Dhule MS, 424005, India
Maneesha Bhardwaj
Department of Pharmacognosy, Universal Institute of Pharmacy, Lalru-140501, India
Sweta Negi
Department of Pharmacy, Galgotias University Plot No. 2, Yamuna Expy, opposite Buddha International Circuit, Sector 17A, Greater Noida, Uttar Pradesh-203201, India
Kavitha S
Department of Biochemistry, The Apollo University, Chittoor, Andhra Pradesh – 517127, India
Touseef Begum
Department of Pharmaceutical Sciences, Ibn Sina National College for Medical Studies, P.O. Box 31906, Jeddah - 21418, Kingdom of Saudi Arabia
Mohammad Muztaba
Department of Pharmacology, Praduman Singh SPS Pharmacy College, Phutahiya Sansarpur Basti, Uttar Pradesh -272001, India

Abstract

The current work examined UDASP-HB, a novel herbal formulation comprising Urtica dioica methanol leaf extract and Angelica sinensis polysaccharide, for its pharmacological activity. It examined the total flavonoid content and its antioxidant and anti-inflammatory activity. UDASP-HB exhibited high concentrations of flavonoids, with considerable inhibition of lipid peroxidation in egg yolk and liver homogenate model compared with controls. UDASP-HB inhibited COX-1 and COX-2 enzymes and, therefore, can exhibit anti-inflammatory activity. Additionally, six new topical gel formulations and preparations were developed and examined for their physicochemical properties and in vitro drug delivery studies. All six preparations facilitated sustained delivery and effective dermal delivery.

Article Details

Issue
Vol. 28 No. 4 (2025): July - August
Section
Research Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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