Chia Seed Extract Attenuates Streptozotocin-Induced Pancreatic Beta-Cell Dysfunction in Diabetic Rats: Evidence from Functional and Oxidative Stress Biomarkers
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Abstract
Diabetes mellitus has a global prevalence of more than 422 million cases, with progressive beta-cell dysfunction marked by pancreatic dysplasia. This paper appraised the protective influences of chia seed extract (CSE) on beta-cell dysfunction induced by streptozotocin (STZ) in diabetic rats. In this experiment, Wistar rats (160g) were separated into four groups (normal control, diabetic control, and two CSE-treated diabetic groups (250 and 500 mg/kg body weight)). The separation lasted 8 weeks, during which 32 male rats were used. STZ (40mg/kg) was injected intraperitoneally to induce diabetes. The measured parameters included fasting glucose, HbA1c, serum insulin, HOMA-IR, pancreatic enzymes, and oxidative stress markers. CSE treatment dose-dependently lowered fasting glucose (59% reduction at high dose, p<0.001), augmented insulin secretion (p<0.001), diminished HOMA-IR (62% reduction, p<0.001), and highly inhibited oxidative imbalance in pancreatic tissue. The CSE 500mg/kg concentration suppressed malondialdehyde by 59 percent and replenished glutathione by 105 percent. These results indicate that the chia seed extract has strong antidiabetic and antioxidant effects, suppressing STZ-induced pancreatic beta-cell dysfunction by reducing oxidative stress.
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