The Antibacterial Activity of Copper(II) and Nickel(II) Coordinated Compounds Containing a Polyaza Macrocyclic Ligand

Abstract

[CuL](ClO₄)₂ (1) and [NiL](ClO₄)₂ (2) compounds containing a polyaza macrocyclic ligand have been prepared via the reaction of 1,2-diaminopropane, α-methylbenzylamine and formaldehyde in the presence of metal(II) ions, where L = 6,13-dimethyl-3,10-bis(1-phenylethyl)-1,3,5,8,10,12- hexaazacyclotetradecane. The compound 1 and 2 have been characterized by elemental analysis, LC-MS, IR and UV-Vis spectroscopy. The essential structure of two compounds consist of [ML]²⁺ (M = Cu²⁺ and Ni²⁺) cation and two perchlorate anions. Metal-ion center, which is Ni(II) and Cu(II), in each compound is coordinated by four secondary amine nitrogen donors of the macrocyclic ligand and has a square-planar geometry forming five- and six-membered rings. The investigation on the antibacterial activity of newly synthesized Ni(II) and Cu(II) compounds were found to be active against the tested antibacterial of Escherichia coli and Staphylococcus aureus.