ฤทธิ์ต้านมะเร็งช่องปากของสารสกัดจากเมล็ดลิ้นจี่

Abstract

Fruits and vegetables are major sources of antioxidants that have been documented for the treatment and prevention of some cancers. The aim of this study was to determine anticancer activity against human mouth carcinoma cell line and cytotoxicity against normal lymphocytes of litchi seed extract. Percentage of cell viability was determined by MTT assay. The half maximal inhibitory concentration (ICro) of the litchi seed extract was 135.0 pg/ml. Cell viability was decreased significantly at a concentration range of 35.0-175.0 pglml (p<0.05). The extract from litchi seed did not significantly decrease the viability of normal lymphocytes except the highest concentration at 1'15.0 pg/ml. This indicated that methanolic seed extract of litchi specifically inhibited cancer cells and caused minimal effects on normal lymphocytes. Thus, anticancer activity of the extract would be the preliminary information for the development of these recipes to anti-oral cancer modem medicines.