การเตรียม การตรวจสอบคุณลักษณะ และศึกษาการปลดปล่อยยาปฏิชีวนะด้วยจีโอโพลิเมอร์

Abstract

The aims of this study were developed geopolymer matrix for controlled release drug of amoxicillin that are antibiotic drug in the gastric and intestines (pH 1 and pH 6.8 temperature 37 ºC conditions). Three formulations of geopolymer tablet, GeAmSF5, GeAmSF7.5 and GeAmSF10, which differents silica fume content were used in this study. Geopolymer tablets were measured compressive strength and characterized by using 3D laser microscope, XRD and FTIR techniques. The drug-release was analyzed by UV-VIS spectrophotometer. Moreover, the drug-release with various extraction solvent in 2 hours and mathematical modeling of amoxicillin release from geopolymer matrix were also studied. It was found that the amoxicillin in geopolymer tablet showed more drug-release in the gastric (pH 1) than in intestines due to the strong acid could cause structure damages to the geopolymer tablet for part of the aluminum could be leached.  The amoxicillin in geopolymer tablet was less drug-release with various extraction solvents than amoxicillin commercial tablet in 2 hours. Mathematical modeling of amoxicillin release from geopolymer matrix was fitted best with Higuchi model indicating diffusion of the drug out of matrix.