Antimicrobial Activity of Secondary Metabolites from Endophytic Fungus Fusarium sp. Isolated from Eichhornia crassipes Linn.
Article Sidebar
Main Article Content
Abstract
The active metabolites producing endophytic fungus, Fusarium sp., was isolated from Eichhornia crassipes Linn. yielded four compounds: “altersolanol (1)”, “4-hydroxydihydronorjavanicin (2)”, “5-hydroxy-7-methoxy-2-isopropylchromone (3)” and “fusaraichromenone (4)”. Structures of 1-4 were elucidated by analysis of their spectroscopic data. The antimicrobial activity was tested by using four bacteria; methicillin-resistant Staphylococcus aureus (MRSA SK1), Staphylococcus aureus (SA), Escherichia coli (EC) and Pseudomonas aeruginosa ATCC27853 (PA)and two yeast; Cryptococcus neoformans ATCC90112 flucytosine – resistant (CN90112) and Candida albicans ATCC 90028 (CA90028) to adverse effect showed that compound 1 and 3 had moderate antibacterial activity against MRSA, SA, PA and SK1 with same MIC value 16 μg/mL. However, all pure compounds showed relatively low activities to inhibit the growth of CA90028 and CN91112 yeast.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Zhang, G.; Sun, S.; Zhu, T.; Lin, Z.; Gu, J.; Li, D.; Gu, Q. Antiviral Isoindolone Derivertives from an Endophytic Fungus Emericella sp. Associated with Aegiceras corniculatum. Phytochemistry. 2011, 72, 1436-1442.
Uma Anitha, K. P. G.; Mythili, S. Antioxidant and Hepatoprotective Potentials of Novel Endophytic Fungus Achaetomium sp., from Euphorbia hirta. Asian Pacific Journal of Tropical Medicine. 2017, 10(6), 588-593.
Hussain, H.; Kliche-Spory, C.; Al-Harrasi, A.; Al-Rawahi, A.; Abbas, G.; Robert, I.; Schulz, B.; Krohn, K. and Shah, A. Antimicrobial Constituents from Three Endophytic Fungi. Asian Pacific Journal of Tropical Medicine. 2014, 7, 224-227.
Shou-Jie, L.; Xuan, Z.; Xiang-Hua, W. & Chang-Qi, Z. Novel Natural Compounds from Endophytic Fungi with Anticancer Activity. European Journal of Medicinal Chemistry. 2018, 156, 316-343.
Guangfeng, L.; Ping, W.; Jinghua, X.; Lan, L.; Hanxiang, L. & Xiaoyi, W. Asperimides A–D, Anti-Inflammatory Aromatic Butenolides from a Tropical Endophytic Fungus. Aspergillus terreus. Fitoterapia. 2018, 131, 50-54.
Xiaohua, Z.; ZnenquanHu, W.; Yoshida, W.; Hou, S.; Saito, J.; AlexesAvad, K.; E. Hevener, K.; N. Alumasa, J.; Cao, S. Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701. Phytochemistry. 2021, 181, 112545.
Sing, A.; Kumar, J.; Sharma, V.K.; Singh, D.K.; Jay, P.K.; Nishad, H.; Gautam, V.S.; Kharwar, R.N. Phytochemical analysis and antimicrobial activity of an endophytic Fusarium proliferatum (ACQR8), isolated from a folk medicinal plant Cissus quadrangularis L. South African Journal of Botany. 2021, 140, 87-94.
Luo, Q. XingZhao, Y. Two new compounds isolated from the entomogenous fungus Fusarium sp. LGWB-7. Phytochemistry Letters. 2021, 41, 74-77.
Joshi, M.; Kaur, S. In vitro evaluation of antimicrobial activity and phytochemical analysis of Calotropis procera, Eichhornia crassipes and Datura innoxia leaves. Asian Journal of Pharmaceutical and Clinical Research. 2013, 6, 25-28.
Roopa, G.; Madhusudhan, M.C.; Sunil, K.C.R.; Lisa, N.; Calvin, R.; Poornima, R.; Zeinab, N.; Kimi, K.R.; Prakash, H.S.; Geetha, N. Identification of Taxol-producing endophytic fungi isolated from Salacia oblonga through genomic mining approach. Journal of Genetic Engineering and Biotechnology. 2015, 13(2), 119-127.
Supaphon, P.; Phongpaichit, S.; Rukachaisirikul, V.; Sakayaroj, J. Diversity and antimicrobial activity of endophytic fungi isolated from the seagrass Enhalus acoroides. Indian Journal of Marine Sciences. 2014, 43(5), 785-797.
Moussa, M.; Ebrahim, W.; El-Neketi, M.; Mandi, A.; Kurtan, T.; Hartmann, R; Lin, W.; Liu, Z.; Proksch, P. Tetrahydroanthraquinone derivatives from the mangrove-derived endophytic fungus Stemphylium globuliferum. Tetrahedron Letters. 2016, 57(36), 4074-4078.
Kornsakulkarn, J.; Dolsophon, K.; Boonyuen, N.; Boonruangprapa, T.; Rachtawee, P.; Prabpai, S.; Kongsaeree, P.; Thongpanchang, C. Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842. Tetrahedron. 2011, 67, 7540-7547.
Tsui, W-Y.; Brown, G.D. Chromones and chromanones from Baeckea frutescens. Phytochemistry. 1996, 43(4), 871-876.
Boonyaketgoson, S.; Trisuwan, K.; Bussaban, B.; Rukachaisirikul, V. & Phongpaichit, S. Isochromanone Derivatives from the Endophytic Fungus Fusarium sp. PDB51F5. Tetrahedron Letters. 2015, 56, 5076-5078.
Sueke, H.; Kaye, S.; Neal, T.; Murphy, C.; Hall, A.; Whltaker, D.; Tuft, S.; Parry, C. Minimum inhibitor concentrations of standard and novel antimicrobials for isolates from bacterial keratitis. Health Economics and Outcomes Research. 2010, 51, 2519-2554.
Moise-Broder, P.A.; Sakoulas, G.; Eliopouls, G.M.; Schentagg, J.J.; Forrest, A.; Moellerring, R.C. accessory gene regular group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy. Clin Infect Dis. 2004, 38, 1700-1705.
Mahboubi, M.; Bidgoli, F.G. in vitro synergistic efficacy of combination of amphotericin B with Myrtus communis essential oil against clinical isolates of Candida albicans. Phytomedicine. 2010. 17, 771-774.
Barchiesl, F.; Schimizzi, A.M.; Caselli, F.; Novelli, A.; Fallani, S.; Giannini, D.; Arzeni, D.; Di Cesare, S.; Falconi, L.; Fortuna, M.; Giacometti, A. Carle, F.; Mazzei, T.; Scalise, G. Interaction between triazoles and amphotericin B against Cryptococcus neoformans. Antimicrobial Agent and Chemotherapy. 2000. 2435-2441.