ฤทธิ์ต้านแบคทีเรียของสารประกอบแซนโทนจากน้ำยางชะมวง

Abstract

Isolation of the chemical constituents from the latex of Garcinia cowa Roxb. by chromatographic and crystallization technique, yield five previously reported xanthones : Cowagarcinone A (1) 1,3,6-trihydroxy-7methoxy-2,5-bis(3-methyl-2-butenyl)xanthone (2) Cowanin (3) Cowaxanthone (4) and Cowanol (5). Their structures were elucidated based on comparison of physical properties and spectroscopic data with the literature. Antibacterial activity ofthe crude latex and isolated xanthones against Bacillus cereus Bacillus subtuls and Staphylococcus aureus was determined by the broth-dilution method. The results were found that the crude latex showed weak activities to inlibit the growth of B.cereus, B.subtilis and S.aureus with MIC values of 190, 390 and 780 pClmL,respectively. 
          Xanthones 3, 4 and 5 were found to against the growth of B.cereus, B.subtitis and S.aureus. Xanthone 3 showed moderate to inhibit B.cereus, B.subtilis and S.aureuswith MIC values of 4.68,g.37 and37.5pgtmL, respectively. Xanthone 4 showed the best activity against B.subtilis with MIC values of 2.34 pglmL and showed moderate to inhibit B.cereus and S.aureus with MIC values of 18.75 and 75.00 pglmL, respectively. Xanthone 5 exhibited moderate activity against B.cereus, B.subtilis and S.aureus with MIC values of 18.75, g.37 and lgJ5pglmL, respectively. Whereas xanthone I showed no activity to inhibit B.cereus, B.subtilis and S.aureus at 150 us.lmL.