Antioxidant, Anti-α-Amylase and α-Glucosidase Activities Ethanolic Extract from Vernonia amygdalina Leave
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Abstract
From local wisdom, it is found that Vernonia amygdalina is a medicinal plant used for medicinal purposes such as helping to reduce blood sugar and pressure but only few academic supports are still provided. The objective of this study is to determine the total phenolic content, total flavonoids content, antioxidant, α-amylase and α-glucosidase inhibitory activities extract from V. amygdalina leaves. In this study, the leave extract of V. amygdalina showed the total phenolic content at 59.03±0.67 mg GAE/g extract, and total flavonoid content at 22.98±0.21 mg QE/g extract. The antioxidant activity of V. amygdalina leave extract determined using DPPH free radical scavenging method was found with IC50 value of 9.37 ± 1.31 mg/mL. Additionally, the extract from dried leaves of V. amygdalina extracted showed good anti-α-glucosidase and anti-α-amylase activities with IC50 values of 10.39 ± 1.08 and 11.08 ± 0.76 mg/mL, respectively, compared with those of acarbose with IC50 values of 14.08 ± 0.21 and 12.47 ± 0.46 mg/mL respectively. Therefore, extensive studies of biological activity and composition should be conducted to lead the development of products for use in the therapy of free radical related diseases and diabetes.
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ลิขสิทธ์ ของมหาวิทยาลัยเทคโนโลยีราชมงคลพระนครReferences
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