Preparation of Protein Hydrolysates from Spirulina and Their Functional Properties
Keywords:
Spirulina, protein hydrolysates, bioactive peptides, functional propertiesAbstract
Protein from Spirulina is an alternative protein with abundant bioactive peptides that benefit human health, such as antioxidant, anticancer, anti-inflammatory, antihypertensive, anti-obesity, etc. Therefore, protein hydrolysate from Spirulina has functional properties that can be applied to healthy food products. In addition, protein hydrolysates have nutritional benefits for consumers and suitable techno-functional properties for processing manufacturers. Previous articles have reported protein and application from Spirulina, which was non-hydrolysed. In this review, we compiled information related to protein hydrolysate that covered the importance of protein hydrolysate, culture process, harvesting, and hydrolysis protein, including illustrated examples of case studies in the current application of protein hydrolysates from Spirulina microalgae.
References
Bortolini DG, Maciel GM, Fernandes IAA, Pedro AC, Rubio FTV, Branco IG, et al. Functional properties of bioactive compounds from Spirulina spp.: Current status and future trends. Food Chem: Mol Sci 2022;5:100134.
Akbarbaglu Z, Ayaseh A, Ghanbarzadeh B, Sarabandi K. Techno-functional, biological and structural properties of Spirulina platensis peptides from different proteases. Algal Res 2022;66:102755.
Nasri M. Chapter Four - Protein hydrolysates and biopeptides: production, biological activities, and applications in foods and health benefits. A review. Adv Food Nutr Res. 2017;81:109-59.
Liceaga A, Hall F. Nutritional, Functional and Bioactive Protein Hydrolysates. Encyclo Food Chem. 2019:456-64.
Aiello G, Li Y, Boschin G, Bollati C, Arnoldi A, Lammi C. Chemical and biological characterization of spirulina protein hydrolysates: Focus on ACE and DPP-IV activities modulation. J Functi Foods 2019;63:103592.
McCarthy AL, Callaghan YC, Brien NM. Protein Hydrolysates from agricultural crops—bioactivity and potential for functional food development. Agriculture 2013;3(1):112-30.
Silva PCd, Toledo T, Brião V, Bertolin TE, Costa JAV. Development of extruded snacks enriched by bioactive peptides from microalga Spirulina sp. LEB 18. Food Biosci 2021;42:101031.
Soni RA, Sudhakar K, Rana RS. Spirulina – From growth to nutritional product: A review. Trends Food Sci 2017;69:157-71.
Venkataraman LV. Spirulina platensis (Arthrospira): physiology, cell biology and biotechnologym, edited by Avigad Vonshak. J Appl Phycol 1997;9(3):295-6.
Vo TS, Ngo DH, Kim SK. Chapter 19 - Nutritional and pharmaceutical properties of microalgal Spirulina. Handbook of Marine Microalgae. 2015:299-308.
AlFadhly NKZ, Alhelfi N, Altemimi AB, Verma DK, Cacciola F, Narayanankutty A. Trends and technological advancements in the possible food applications of Spirulina and their health benefits: A Review. Molecules 2022;27(17):5584.
Akbarbaglu Z, Ayaseh A, Ghanbarzadeh B, Sarabandi K. Biological stabilization of Arthrospira bioactive-peptides within biopolymers: Functional food formulation; bitterness-masking and nutritional aspects. LWT 2024;191:115653.
Matufi F, Choopani A. Spirulina, food of past, present and future. Health Biotechnol Biopharm 2020;3(4):1-20.
Li Y, Aiello G, Bollati C, Bartolomei M, Arnoldi A, Lammi C. Phycobiliproteins from Arthrospira platensis (Spirulina): A new source of peptides with dipeptidyl peptidase-IV inhibitory activity. Nutrients 2020;12(3):794.
Ovando CA, Carvalho JC, Pereira GVM, Jacques P, Soccol VT, Soccol CR. Functional properties and health benefits of bioactive peptides derived from Spirulina: A review. Food Rev Int 2018;34(1):34-51.
Adeyeye E, Ayeni S. Comparability of the amino acid composition of whole egg and two fancy meats (heart and liver) of domestic duck (Anas platyrhynchos) consumed in Nigeria. OJACR 2014;2(1):16-28.
Anaeto M, Adeyeye JA, Chioma G, Olarinmoye A, Tayo O. Goat Products: Meeting the challenges of human health and nutrition. Agric Biol J N Am 2010;1(6):1231-6.
Gorissen SHM, Crombag JJR, Senden JMG, Waterval WAH, Bierau J, Verdijk LB, et al. Protein content and amino acid composition of commercially available plant-based protein isolates. Amino Acids 2018;50(12):1685-95.
Derbyshire E. Food-Based dietary guidelines and protein quality definitions-Time to move forward and encompass mycoprotein? Foods 2022;11(5):647.
Ward FM, Deyab MA. Comparative study of nutritional importance of some marine macroalgae as a novel natural source of amino acids. Russ J Mar Biol 2021;47:39-46.
Raczyk M, Polanowska K, Kruszewski B, Grygier A, Michałowska D. Effect of Spirulina (Arthrospira platensis) supplementation on physical and chemical properties of semolina (Triticum durum) based fresh pasta. Molecules 2022;27(2):355.
Tiong I, Yeong ys, Jusoh M, Wahid E, Nagappan T. Chlorella vulgaris : a perspective on its potential for combining high biomass with high value bioproducts. Appl Phycol 2020;1(1):2-11.
Chatterjee C, Gleddie S, Xiao CW. Soybean bioactive peptides and their functional properties. Nutrients 2018;10(9):1211.
Helal A, Tagliazucchi D. Peptidomics profile, bioactive peptides identification and biological activities of six different cheese varieties. Biology 2023;12(1):78.
Abdel-Hamid M, Otte J, De Gobba C, Osman A, Hamad E. Angiotensin I-converting enzyme inhibitory activity and antioxidant capacity of bioactive peptides derived from enzymatic hydrolysis of buffalo milk proteins. Int Dairy J 2017;66:91-8.
Wang X, Chen H, Fu X, Li S, Wei J. A novel antioxidant and ACE inhibitory peptide from rice bran protein: Biochemical characterization and molecular docking study. LWT 2017;75:93-9.
Anekthanakul K, Senachak J, Hongsthong A, Charoonratana T, Ruengjitchatchawalya M. Natural ACE inhibitory peptides discovery from Spirulina (Arthrospira platensis) strain C1. Peptides 2019;118:170107.
Yan QJ, Huang LH, Sun Q, Jiang ZQ, Wu X. Isolation, identification and synthesis of four novel antioxidant peptides from rice residue protein hydrolyzed by multiple proteases. Food Chem 2015;179:290-5.
Bougatef A, Nedjar-Arroume N, Manni L, Ravallec R, Barkia A, Guillochon D, et al. Purification and identification of novel antioxidant peptides from enzymatic hydrolysates of sardinelle (Sardinella aurita) by-products proteins. Food Chem 2010;118(3):559-65.
Wang L, Dong C, Li X, Han W, Su X. Anticancer potential of bioactive peptides from animal sources (Review). Oncol Rep 2017;38(2):637-51.
Wang Z, Zhang X. Isolation and identification of anti-proliferative peptides from Spirulina platensis using three-step hydrolysis. J Sci Food Agric 2017;97(3):918-22.
Vo TS, Ngo DH, Kang KH, Park SJ, Kim SK. The role of peptides derived from Spirulina maxima in downregulation of FcεRI-mediated allergic responses. Mol Nutr Food Res 2014;58(11):2226-34.
Usharani G, Saranraj P, Kanchana D. Spirulina Cultivation: A Review. IJPBA. 2012;3(6):1327-41.
Ismail I, Kurnia KA, Samsuri S, Bilad MR, Marbelia L, Ismail NM, et al. Energy efficient harvesting of Spirulina sp. from the growth medium using a tilted panel membrane filtration. Bioresour Technol Rep 2021;15:100697.
Stunda-Zujeva A, Veģere K. Growing and drying Spirulina/Arthrospira for producing food and nutraceuticals: A Review. KEM 2018;762:134-40.
Stramarkou M, Papadaki S, Kyriakopoulou K, Tzovenis I, Chronis M, Krokida M. Comparative analysis of different drying techniques based on the qualitative characteristics of Spirulina platensis biomass. J Aquat Food Prod 2021;30(5):498-516.
Ashaolu TJ. Applications of soy protein hydrolysates in the emerging functional foods: A Review. Int J Food Sci Technol 2019;55(2):421-8.
Pratama AI, Lioe HN, Yuliana ND, Ogawa M. Umami compounds present in umami fraction of acid-hydrolyzed Spirulina (Spirulina platensis). Algal Res 2022;66:102764.
Mohammadi M, Soltanzadeh M, Ebrahimi AR, Hamishehkar H. Spirulina platensis protein hydrolysates: Techno-functional, nutritional and antioxidant properties. Algal Res 2022;65:102739.
Sahin B, Hosoglu MI, Guneser O, Karagul-Yuceer Y. Fermented Spirulina products with Saccharomyces and non- Saccharomyces yeasts: Special reference to their microbial, physico-chemical and sensory characterizations. Food Biosci 2022;47:101691.
Ma J, Zeng X, Zhou M, Cheng L, Ren D. Inhibitory effect of low-molecular-weight peptides (0–3 kDa) from Spirulina platensis on H2O2-induced oxidative damage in L02 human liver cells. Bioresour Bioprocess 2021;8(1):36.
Jie Y, Yuanliang H, Mingxiong X, Yaohao D, Shenao L, Nan P, et al. Purification and identification of antioxidant peptides from enzymatic hydrolysate of Spirulina platensis. J Microbiol Biotechnol 2016;26(7):1216-23.
Zhang N, Li F, Zhang T, Li C-Y, Zhu L, Yan S. Isolation, identification, and molecular docking analysis of novel ACE inhibitory peptides from Spirulina platensis. Eur Food Res Technol 2022;248(4):1107-15.
Sun Y, Chang R, Li Q, Li B. Isolation and characterization of an antibacterial peptide from protein hydrolysates of Spirulina platensis. Eur Food Res Technol 2016;242(5):685-92.
MubarakAli D, MohamedSaalis J, Sathya R, Irfan N, Kim JW. An evidence of microalgal peptides to target spike protein of COVID-19: In silico approach. Microb Pathog 2021;160:105189.
Wang Z, Zhang X. Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth. Food Funct 2016;7(2):781-8.
Moghadamzadegan S, Emtyazjoo M, Sadeghi M, Rabbani M. Evaluation of anti-inflammatory effects of bioactive peptides of Spirulina platensis extracted by animal cysteine protease enzyme in mice Balb/C. J Anim Biol 2021;13(4):119-32.
Bingli Z, Cui Y, Xiaodan F, Qi P, Liu C, Zhou X, et al. Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice. PLoS One 2019;14(6):e0218543.
Lee C-W, Chang YB, Park CW, Han SH, Suh HJ, Ahn Y. Protein hydrolysate from Spirulina platensis prevents dexamethasone-induced muscle atrophy via Akt/Foxo3 signaling in C2C12 myotubes. Mar Drugs 2022;20(6):365.
Villaseñor VM, Enriquez-Vara JN, Urías-Silva JE, Mojica L. Edible Insects: Techno-functional properties food and feed applications and biological potential. Food Rev Int 2022;38(sup1):866-92.
Akbarbaglu Z, Ayaseh A, Ghanbarzadeh B, Sarabandi K, Kharazmi MS, Jafari SM. Chemical structure and bio-functional properties of Arthrospira platensis peptides produced by ultrasonication-enzymolysis: their emulsification capabilities. Process Biochem 2023;132:191-9.
Cristiane R, Pereira A, Costa JA. Biopeptides with antioxidant activity extracted from the biomass of Spirulina sp. LEB 18. Afr J Microbiol Res 2016;10(3):79-86.
Forutan M, Hasani M, Hasani S, Salehi N. Antioxidative activity and functional properties of enzymatic protein hydrolysate of Spirulina platensis. J Food Biosci Technol 2023;13(1):75-89.
Forutan M, Hasani M, Hasani S, Salehi N, Sabbagh F. Liposome system for encapsulation of Spirulina platensis protein hydrolysates: controlled-release in simulated gastrointestinal conditions, structural and functional Properties. Materials 2022;15(23):8581.
Maag P, Dirr S, Özmutlu Karslioglu Ö. Investigation of bioavailability and food-processing properties of Arthrospira platensis by enzymatic treatment and micro-encapsulation by spray drying. Foods 2022;11(13):1922.
Villaró-Cos S, Guzmán Sánchez JL, Acién G, Lafarga T. Research trends and current requirements and challenges in the industrial production of Spirulina as a food source. Trends Food Sci Technol 2024;143:104280.
Mohammadi M, Hamishehkar H, McClements DJ, Shahvalizadeh R, Barri A. Encapsulation of Spirulina protein hydrolysates in liposomes: Impact on antioxidant activity and gastrointestinal behavior. Food Chem 2023;400:133973.
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